Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer - Test2 - elhamkhani - TriplyDB

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

http://www.wikidata.org/entity/Q24553135

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The expression of the ubiquitin ligase subunit Cks1 in human breast cancer Algorithm-driven artifacts in median polish summarization of microarray data Acetylation-dependent regulation of Skp2 function Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation The role of the ubiquitination-proteasome pathway in breast cancer: use of mouse models for analyzing ubiquitination processes Redefinition of Affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements.Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway Breast cancer molecular subtypes: from TNBC to QNBC Repeated observation of breast tumor subtypes in independent gene expression data sets Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1 Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Exploring the molecular pathogenesis and biomarkers of high risk oral premalignant lesions on the basis of long noncoding RNA expression profiling by serial analysis of gene expression.Correction of technical bias in clinical microarray data improves concordance with known biological information.Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes.Nuclear translocation of Skp2 facilitates its destruction in response to TGFβ signaling.The ubiquitin system, disease, and drug discovery.Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer.Regulation of Skp2 levels by the Pim-1 protein kinase Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells.Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.Ezetimibe prevents the development of non‑alcoholic fatty liver disease induced by high‑fat diet in C57BL/6J mice.Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.Skp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer.Mitogenic Signaling by the gep Oncogene Involves the Upregulation of S-Phase Kinase-Associated Protein 2.Roles of F-box proteins in cancer Phosphorylation of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic function of S-phase kinase-associated protein-2 (Skp2).Geminin overexpression promotes imatinib sensitive breast cancer: a novel treatment approach for aggressive breast cancers, including a subset of triple negative Relation of overexpression of S phase kinase-associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma.BRCA1 functions as a breast stem cell regulator.Identification of sample-specific regulations using integrative network level analysis Silencing of GSTP1, a prostate cancer prognostic gene, by the estrogen receptor-β and endothelial nitric oxide synthase complex.

P2860

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P2860

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

http://www.wikidata.org/entity/Q24553135

description

2002 nî lūn-bûn

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2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@ast

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@en

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@nl

type

label

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@ast

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@en

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@nl

prefLabel

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@ast

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@en

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@nl

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Journal of Clinical Investigation

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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

@en

P2093

Andrea Richardson

http://www.w3.org/2001/XMLSchema#string

Beth Isaac

http://www.w3.org/2001/XMLSchema#string

Franco Monti

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Lucia Di Marcotullio

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Montserrat Rue

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Sabina Signoretti

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Sridhar Ramaswamy

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P2860

The F-box protein family.

Identification of a family of human F-box proteins

A family of mammalian F-box proteins

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

Role of the F-box protein Skp2 in lymphomagenesis

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Gene expression profiling predicts clinical outcome of breast cancer

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

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10.1172/JCI0215795

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10.1172/JCI15795

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5

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12208864

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151109

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