Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation - Test2 - elhamkhani - TriplyDB

Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation

Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation

http://www.wikidata.org/entity/Q24554287

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Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway MEKK1 binds raf-1 and the ERK2 cascade components A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components.Requirement of the JIP1 scaffold protein for stress-induced JNK activation Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation Olive (Olea europaea) leaf extract induces apoptosis and monocyte/macrophage differentiation in human chronic myelogenous leukemia K562 cells: insight into the underlying mechanism.Different protein kinase C isoforms determine growth factor specificity in neuronal cells MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.MEKK2 mediates an alternative β-catenin pathway that promotes bone formation Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway.Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.MEKK3 is essential for lipopolysaccharide-induced interleukin-6 and granulocyte-macrophage colony-stimulating factor production in macrophages.Dimerization through the catalytic domain is essential for MEKK2 activation.Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling.The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.The More We Know, the Less We Understand?: Complexity of MAP Kinase Signaling.Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes.OMTK1, a novel MAPKKK, channels oxidative stress signaling through direct MAPK interaction.MEKK2 kinase association with 14-3-3 protein regulates activation of c-Jun N-terminal kinase.MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression.Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase.Gene expression in Sinclair swine with malignant melanoma.MiR-17-5p and miR-20a promote chicken cell proliferation at least in part by upregulation of c-Myc via MAP3K2 targeting.Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia.A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.

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Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation

http://www.wikidata.org/entity/Q24554287

description

2000 nî lūn-bûn

@nan

2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2000 թվականի ապրիլին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Synergistic interaction of MEK ...... t and specific JNK1 activation

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Synergistic interaction of MEK ...... t and specific JNK1 activation

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Synergistic interaction of MEK ...... t and specific JNK1 activation

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Synergistic interaction of MEK ...... t and specific JNK1 activation

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Synergistic interaction of MEK ...... t and specific JNK1 activation

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Synergistic interaction of MEK ...... t and specific JNK1 activation

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prefLabel

Synergistic interaction of MEK ...... t and specific JNK1 activation

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Synergistic interaction of MEK ...... t and specific JNK1 activation

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Synergistic interaction of MEK ...... t and specific JNK1 activation

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MCB.20.7.2334-2342.2000

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Molecular and Cellular Biology

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Synergistic interaction of MEK ...... t and specific JNK1 activation

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P2093

B Su

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J Cheng

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M Karin

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Y Xia

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P2860

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

Components of a new human protein kinase signal transduction pathway

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

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2334-42

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10.1128/MCB.20.7.2334-2342.2000

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10713157

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85399

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