The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
about
Nijmegen breakage syndrome (NBS)Chk1 suppressed cell deathSIRT1 regulates the function of the Nijmegen breakage syndrome proteinRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringProapoptotic Bid mediates the Atr-directed DNA damage response to replicative stressCommon mechanisms of PIKK regulationDNA End Resection: Facts and MechanismsATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorModeling the study of DNA damage responses in miceRecruitment and activation of the ATM kinase in the absence of DNA-damage sensors.Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingAberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing geneZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing overChk2 suppresses the oncogenic potential of DNA replication-associated DNA damageATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevisThe MRN complex in double-strand break repair and telomere maintenance.DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesionsTargeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase.New insights into the link between DNA damage and apoptosis.cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cellsKinase-independent functions of TEL1 in telomere maintenance.ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks.Regulation of DNA damage responses and cell cycle progression by hMOB2.Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation.Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymesEXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.Functions of the MRE11 complex in the development and maintenance of oocytesPhosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapyDecoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells.The ATM signaling network in development and disease.The involvement of DNA-damage and -repair defects in neurological dysfunctionMre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl.DNA double-strand break repair and development.Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability
P2860
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P2860
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
@en
type
label
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
@en
prefLabel
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
@en
P2093
P2860
P356
P1433
P1476
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
@en
P2093
Hussein Hussein
John H J Petrini
Monica Morales
Suzana S Couto
P2860
P2888
P304
P356
10.1038/NATURE05740
P407
P577
2007-04-11T00:00:00Z
P5875
P6179
1048771444