Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a - Test2 - elhamkhani - TriplyDB

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

http://www.wikidata.org/entity/Q24613036

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Melanoma genome sequencing reveals frequent PREX2 mutations The PTEN tumor suppressor gene and its role in lymphoma pathogenesis Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease PTEN modulators: a patent review Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Therapeutic targeting of cancers with loss of PTEN function.Regulation and function of P-Rex family Rac-GEFs A secreted PTEN phosphatase that enters cells to alter signaling and survival Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth.Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation.Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.PI3K: from the bench to the clinic and back.PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control Genetic determinants at the interface of cancer and neurodegenerative disease.The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells.Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling.Genetics of hypertension and cardiovascular disease and their interconnected pathways: lessons from large studies.Protein interactions of phosphatase and tensin homologue (PTEN) and its cancer-associated G20E mutant compared by using stable isotope labeling by amino acids in cell culture-based parallel affinity purification.The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.Coordination between p21 and DDB2 in the cellular response to UV radiation.Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Rac signaling in breast cancer: a tale of GEFs and GAPs.Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma.Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study.PTEN at a glance.

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P2860

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

http://www.wikidata.org/entity/Q24613036

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2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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SCIENCE.1173569

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Activation of the PI3K pathway ...... TEN by exchange factor P-REX2a

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P2860

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

P-Rex2, a new guanine-nucleotide exchange factor for Rac

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

PTEN function: how normal cells control it and tumour cells lose it

The phosphoinositide 3-kinase pathway

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

The consensus coding sequences of human breast and colorectal cancers

PTEN: one gene, many syndromes

Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids

PTEN associates with the vault particles in HeLa cells

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