TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle - Test2 - elhamkhani - TriplyDB

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

http://www.wikidata.org/entity/Q24635228

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Identification of a TPX2-like microtubule-associated protein in Drosophila Kinesin-5: cross-bridging mechanism to targeted clinical therapy Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly The Ran Pathway in Drosophila melanogaster Mitosis TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux.Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule.Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus.A versatile multivariate image analysis pipeline reveals features of Xenopus extract spindles.Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2.Development of a Drosophila cell-based error correction assay.Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics.Eg5 restricts anaphase B spindle elongation in mammalian cells.Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts.CENP-W plays a role in maintaining bipolar spindle structure.Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly.TPX2 regulates neuronal morphology through kinesin-5 interaction.Modular aspects of kinesin force generation machinery Suppression of microtubule assembly kinetics by the mitotic protein TPX2.Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I.Microtubules and Growth Cones: Motors Drive the Turn Rho GTPase-independent regulation of mitotic progression by the RhoGEF Net1 Spatial organization of the Ran pathway by microtubules in mitosis Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.The sequential activation of the mitotic microtubule assembly pathways favors bipolar spindle formation The molecular basis for kinesin functional specificity during mitosis.TPX2: of spindle assembly, DNA damage response, and cancer.Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes.Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death.TPX2.Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS.APC/C is an essential regulator of centrosome clustering.Src family kinase phosphorylation of the motor domain of the human kinesin-5, Eg5.She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain.Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice.The non-motor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation.P190RhoGAP prevents mitotic spindle fragmentation and is required to activate Aurora A kinase at acentriolar poles.Spindle assembly in egg extracts of the Marsabit clawed frog, Xenopus borealis.

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P2860

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

http://www.wikidata.org/entity/Q24635228

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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name

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

@ast

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

@en

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

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type

label

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

@ast

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

@en

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

@nl

prefLabel

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

@ast

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

@en

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

@nl

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TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

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P2093

Alyssa Gable

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Janel Titus

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Nan Ma

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Patricia Wadsworth

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P2860

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding

Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

Human TPX2 is required for targeting Aurora-A kinase to the spindle

hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells

HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.

Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles.

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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87-98

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scholarly article

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2277546

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10.1083/JCB.201106149

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1

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195

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Jennifer L Ross

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2011-10-03T00:00:00Z

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51691131

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21969468

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3187703

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