Xenopus Cdc6 performs separate functions in initiating DNA replication - Test2 - elhamkhani - TriplyDB

Xenopus Cdc6 performs separate functions in initiating DNA replication

Xenopus Cdc6 performs separate functions in initiating DNA replication

http://www.wikidata.org/entity/Q33608362

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Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells Xenopus origin recognition complex (ORC) initiates DNA replication preferentially at sequences targeted by Schizosaccharomyces pombe ORC.Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation.Oncogenic activity of Cdc6 through repression of the INK4/ARF locus.Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase.MCM2-7 form double hexamers at licensed origins in Xenopus egg extract.Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.Metazoan origin selection: origin recognition complex chromatin binding is regulated by CDC6 recruitment and ATP hydrolysis.Dynamics of DNA binding of replication initiation proteins during de novo formation of pre-replicative complexes in Xenopus egg extracts.Inter-origin cooperativity of geminin action establishes an all-or-none switch for replication origin licensing.MCM interference during licensing of DNA replication in Xenopus egg extracts-Possible Role of a C-terminal region of MCM3.Study of DNA replication in Drosophila using cell free in vitro system.

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P2860

Xenopus Cdc6 performs separate functions in initiating DNA replication

http://www.wikidata.org/entity/Q33608362

description

2002 nî lūn-bûn

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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2002年の論文

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2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Xenopus Cdc6 performs separate functions in initiating DNA replication

@ast

Xenopus Cdc6 performs separate functions in initiating DNA replication

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type

label

Xenopus Cdc6 performs separate functions in initiating DNA replication

@ast

Xenopus Cdc6 performs separate functions in initiating DNA replication

@en

prefLabel

Xenopus Cdc6 performs separate functions in initiating DNA replication

@ast

Xenopus Cdc6 performs separate functions in initiating DNA replication

@en

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P2860

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P1433

Molecular Biology of the Cell

P1476

Xenopus Cdc6 performs separate functions in initiating DNA replication

@en

P2093

Nadia Tikhmyanova

http://www.w3.org/2001/XMLSchema#string

Nancy Schek

http://www.w3.org/2001/XMLSchema#string

Natalya S Frolova

http://www.w3.org/2001/XMLSchema#string

Thomas R Coleman

http://www.w3.org/2001/XMLSchema#string

P2860

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

A human protein related to yeast Cdc6p

Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system.

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold

Identification and characterization of a human protein kinase related to budding yeast Cdc7p

Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2

P304

1298-1312

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P31

scholarly article

P356

10.1091/MBC.01-08-0382

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4

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P478

13

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2002-04-01T00:00:00Z

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11415917

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11950940

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P932

102270

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