The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin - Test2 - elhamkhani - TriplyDB

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

http://www.wikidata.org/entity/Q24671706

about

The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression Regulation of c-Src by binding to the PDZ domain of AF-6 ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion.The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain Control of Dendritic Spine Morphological and Functional Plasticity by Small GTPases Molecular insights on context-specific role of profilin-1 in cell migration The roles of claudin superfamily proteins in paracellular transport Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis Rap1 activation is required for Fc gamma receptor-dependent phagocytosis Loss of Rap1GAP in papillary thyroid cancer Slit diaphragms contain tight junction proteins Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.Afadin is localized at cell-cell contact sites in mesangial cells and regulates migratory polarity.Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells.Human RAS superfamily proteins and related GTPases.Control of cell adhesion dynamics by Rap1 signaling.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1.Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.AF6 negatively regulates Rap1-induced cell adhesion.Activation and function of the Rap1 GTPase in B lymphocytes.The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo.Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function.Dubble or nothing? Is HAUSP deubiquitylating enzyme the final arbiter of p53 levels?Regulator of G-Protein Signalling-14 (RGS14) Regulates the Activation of αMβ2 Integrin during Phagocytosis.Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium.Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation.Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosan particles in macrophages Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function.Discontinuities in Rap1 activity determine epithelial cell morphology within the developing wing of Drosophila.

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P2860

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

http://www.wikidata.org/entity/Q24671706

description

2000 nî lūn-bûn

@nan

2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2000年の論文

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年學術文章

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name

The junctional multidomain pro ...... ytoskeletal regulator profilin

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The junctional multidomain pro ...... ytoskeletal regulator profilin

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The junctional multidomain pro ...... ytoskeletal regulator profilin

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type

label

The junctional multidomain pro ...... ytoskeletal regulator profilin

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The junctional multidomain pro ...... ytoskeletal regulator profilin

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The junctional multidomain pro ...... ytoskeletal regulator profilin

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prefLabel

The junctional multidomain pro ...... ytoskeletal regulator profilin

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The junctional multidomain pro ...... ytoskeletal regulator profilin

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The junctional multidomain pro ...... ytoskeletal regulator profilin

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P1433

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PNAS.97.16.9064

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Proceedings of the National Academy of Sciences of the United States of America

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The junctional multidomain pro ...... ytoskeletal regulator profilin

@en

P2093

B Boettner

http://www.w3.org/2001/XMLSchema#string

E E Govek

http://www.w3.org/2001/XMLSchema#string

J Cross

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L Van Aelst

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P2860

M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation

A ras-related gene with transformation suppressor activity

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins

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10922060

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