The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain
about
c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1Bcr interferes with beta-catenin-Tcf1 interactionRegulation of c-Src by binding to the PDZ domain of AF-6The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activitySolution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complexIdentification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localizationAbr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled.Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution.Bcr is a negative regulator of the Wnt signalling pathwayCLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation.Control of synapse development and plasticity by Rho GTPase regulatory proteins.Small-molecule inhibitors of AF6 PDZ-mediated protein-protein interactions.Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancerThe functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemiaKaposi's sarcoma-associated herpesvirus microRNAs repress breakpoint cluster region protein expression, enhance Rac1 activity, and increase in vitro angiogenesis.PHF10 is required for cell proliferation in normal and SV40-immortalized human fibroblast cellsSynaptic plasticity, a symphony in GEF.PDZ domains: the building blocks regulating tumorigenesis.Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression.Characterization of nectin processing mediated by presenilin-dependent γ-secretase.Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium.Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1.Essential role of p38gamma in K-Ras transformation independent of phosphorylation.Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate.Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site.Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor.Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia.The genomic landscape of two Burkitt lymphoma cases and derived cell lines: comparison between primary and relapse samples.Modelling Cooperative Tumorigenesis in Drosophila.Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple.
P2860
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P2860
The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@ast
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@en
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@nl
type
label
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@ast
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@en
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@nl
prefLabel
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@ast
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@en
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@nl
P2093
P2860
P1476
The Bcr kinase downregulates R ...... and binding to its PDZ domain
@en
P2093
G Radziwill
K Moelling
R A Erdmann
U Margelisch
P2860
P304
P356
10.1128/MCB.23.13.4663-4672.2003
P407
P577
2003-07-01T00:00:00Z