Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies - Test2 - elhamkhani - TriplyDB

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

http://www.wikidata.org/entity/Q24672400

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Akt isoforms in vascular disease Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance mTOR signaling in tumorigenesis Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.Disassociation of insulin action and Akt/FOXO signaling in skeletal muscle of older Akt-deficient mice.Akt3 is responsible for the survival and proliferation of embryonic stem cells Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone.Akt isoforms differentially regulate neutrophil functions Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.Deletion of PKBalpha/Akt1 affects thymic development The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation.Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation.Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin Signaling specificity in the Akt pathway in biology and disease.The critical role of AKT2 in hepatic steatosis induced by PTEN loss.Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease.Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.Akt1 deletion prevents lung tumorigenesis by mutant K-ras.Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil.Akt is required for Stat5 activation and mammary differentiation.Motor neuron trophic factors: therapeutic use in ALS?Distinct actions of akt1 on skeletal architecture and function Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.Validation of Tuba1a as appropriate internal control for normalization of gene expression analysis during mouse lung development.Photoactivation of Akt1/GSK3β Isoform-Specific Signaling Axis Promotes Pancreatic β-Cell Regeneration.Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle.Depletion of Amyloid Precursor Protein (APP) causes G0 arrest in non-small cell lung cancer (NSCLC) cells.

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Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

http://www.wikidata.org/entity/Q24672400

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2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年论文

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Life with a single isoform of ...... stasis and growth deficiencies

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Life with a single isoform of ...... stasis and growth deficiencies

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Molecular and Cellular Biology

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Life with a single isoform of ...... stasis and growth deficiencies

@en

P2093

Bettina Dummler

http://www.w3.org/2001/XMLSchema#string

Brian A Hemmings

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Debby Hynx

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Oliver Tschopp

http://www.w3.org/2001/XMLSchema#string

Stephan Dirnhofer

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Zhong-Zhou Yang

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P2860

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Evolution of protein kinase signaling from yeast to man

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

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4553809

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10.1128/MCB.00722-06

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21

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26

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1636753

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