Akt isoforms differentially regulate neutrophil functions - Test2 - elhamkhani - TriplyDB

Akt isoforms differentially regulate neutrophil functions

Akt isoforms differentially regulate neutrophil functions

http://www.wikidata.org/entity/Q30494741

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Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes Kinase AKT controls innate immune cell development and function Akt isoforms in vascular disease Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation Technical note: proteomic approaches to fundamental questions about neutrophil biology.Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung.Protein kinase B (AKT) mediates phospholipase D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells.Anti-inflammatory effects of secondary metabolites of marine Pseudomonas sp. in human neutrophils are through inhibiting P38 MAPK, JNK, and calcium pathways.Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density Platelet-neutrophil interactions under thromboinflammatory conditions Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2 Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) Domain Intermittent Hypoxia Affects the Spontaneous Differentiation In Vitro of Human Neutrophils into Long-Lived Giant Phagocytes.Hydroxyurea with AKT2 inhibition decreases vaso-occlusive events in sickle cell disease mice Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells.G-CSF activation of AKT is not sufficient to prolong neutrophil survival The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin.Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease.Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases.Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils.Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy.Regulation of innate immune cell function by mTOR.Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis.Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization.AKT/PKB Signaling: Navigating the Network.Ser/Thr protein kinase Bβ-NADPH oxidase 2 signaling in thromboinflammation.

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P2860

Akt isoforms differentially regulate neutrophil functions

http://www.wikidata.org/entity/Q30494741

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Akt isoforms differentially regulate neutrophil functions

@ast

Akt isoforms differentially regulate neutrophil functions

@en

type

label

Akt isoforms differentially regulate neutrophil functions

@ast

Akt isoforms differentially regulate neutrophil functions

@en

prefLabel

Akt isoforms differentially regulate neutrophil functions

@ast

Akt isoforms differentially regulate neutrophil functions

@en

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BLOOD-2009-11-255323

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P1476

Akt isoforms differentially regulate neutrophil functions

@en

P2093

Haiyang Tang

http://www.w3.org/2001/XMLSchema#string

Jia Chen

http://www.w3.org/2001/XMLSchema#string

Jingsong Xu

http://www.w3.org/2001/XMLSchema#string

Nissim Hay

http://www.w3.org/2001/XMLSchema#string

Richard D Ye

http://www.w3.org/2001/XMLSchema#string

P2860

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.

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10.1182/BLOOD-2009-11-255323

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21

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20332370

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2879106

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