Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model
about
The HTLV-1 Tax interactomep31comet blocks Mad2 activation through structural mimicryNuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitorStructural analysis of Bub3 interactions in the mitotic spindle checkpointBub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesisChemical Structure-Biological Activity Models for Pharmacophores' 3D-InteractionsComplex Commingling: Nucleoporins and the Spindle Assembly CheckpointThe current view for the silencing of the spindle assembly checkpointCdc20 is critical for meiosis I and fertility of female miceInsights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 DimerMad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpointThe HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpointRecruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylationThe kinetochore-dependent and -independent formation of the CDC20-MAD2 complex and its functions in HeLa cellsDisruption of FAT10-MAD2 binding inhibits tumor progression.A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes.Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control.Hurp deficiency in mice leads to female infertility caused by an implantation defect.Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint.Mammalian chromosomes contain cis-acting elements that control replication timing, mitotic condensation, and stability of entire chromosomes.Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancerOverexpression of p42.3 promotes cell growth and tumorigenicity in hepatocellular carcinomaHistone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switchingRequirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1).Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinaseProtein metamorphosis: the two-state behavior of Mad2.Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesisMAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous CarcinomaMonitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.An overview of the spindle assembly checkpoint status in oral cancer.Emerging links among Chromosome Instability (CIN), cancer, and aging.The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).All together now: Polo joins the kinase network controlling the spindle assembly checkpoint in Drosophila.Novel mad2 alleles isolated in a Schizosaccharomyces pombe gamma-tubulin mutant are defective in metaphase arrest activity, but remain functional for chromosome stability in unperturbed mitosis.
P2860
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P2860
Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model
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2006 nî lūn-bûn
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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2006 թվականի ապրիլին հրատարակված գիտական հոդված
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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name
Structural activation of Mad2 ...... versus the Mad2 template model
@ast
Structural activation of Mad2 ...... versus the Mad2 template model
@en
Structural activation of Mad2 ...... versus the Mad2 template model
@nl
type
label
Structural activation of Mad2 ...... versus the Mad2 template model
@ast
Structural activation of Mad2 ...... versus the Mad2 template model
@en
Structural activation of Mad2 ...... versus the Mad2 template model
@nl
prefLabel
Structural activation of Mad2 ...... versus the Mad2 template model
@ast
Structural activation of Mad2 ...... versus the Mad2 template model
@en
Structural activation of Mad2 ...... versus the Mad2 template model
@nl
P2860
P921
P3181
P356
P1476
Structural activation of Mad2 ...... versus the Mad2 template model
@en
P2093
Hongtao Yu
P2860
P3181
P356
10.1083/JCB.200601172
P407
P577
2006-04-24T00:00:00Z