Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 - Test2 - elhamkhani - TriplyDB

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

http://www.wikidata.org/entity/Q24670095

about

Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships Deficient spindle assembly checkpoint in multiple myeloma Reverse engineering of the spindle assembly checkpoint The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3 Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint ZW10 links mitotic checkpoint signaling to the structural kinetochore.Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells Shugoshin is a Mad1/Cdc20-like interactor of Mad2 The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.Determinants of conformational dimerization of Mad2 and its inhibition by p31comet Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.Identification of a MAD2-binding protein, CMT2, and its role in mitosis.APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint Mammalian Cdh1/Fzr mediates its own degradation Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20 Linking kinetochore-microtubule binding to the spindle checkpoint Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.A new view of the spindle checkpoint Structural analysis of Bub3 interactions in the mitotic spindle checkpoint Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution The multifaceted roles of the HORMA domain in cellular signaling Antimitotic drugs in the treatment of cancer Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint

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Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

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2001 nî lūn-bûn

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2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年學術文章

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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Checkpoint inhibition of the A ...... f BUBR1, BUB3, CDC20, and MAD2

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V Sudakin

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P2860

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase

Identification of a human mitotic checkpoint gene: hsMAD2

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

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10.1083/JCB.200102093

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5

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154

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11535616

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mitotic checkpoint complex

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2196190

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