Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex
about
The function of APC/CCdh1 in cell cycle and beyondZW10 links mitotic checkpoint signaling to the structural kinetochore.Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.Determinants of conformational dimerization of Mad2 and its inhibition by p31cometMechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complexProbing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpointNuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitorA requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpointConformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointThe APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.Structural analysis of Bub3 interactions in the mitotic spindle checkpointRapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cellsMicrotubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signalingHuman MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochoresHURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template modelProphase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionComplex Commingling: Nucleoporins and the Spindle Assembly CheckpointFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisDefining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 InhibitionStructural analysis of human Cdc20 supports multisite degron recognition by APC/CStructure of the mitotic checkpoint complexTwo complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae.The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpointSpatiotemporal regulation of the anaphase-promoting complex in mitosisMad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpointIn-silico modeling of the mitotic spindle assembly checkpointThe anaphase promoting complex/cyclosome: a machine designed to destroyPlx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores.Genetic analysis of the spindle checkpoint genes san-1, mdf-2, bub-3 and the CENP-F homologues hcp-1 and hcp-2 in Caenorhabditis elegans.Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stabilityRecruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mice.Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing.Disruption of astral microtubule contact with the cell cortex activates a Bub1, Bub3, and Mad3-dependent checkpoint in fission yeast
P2860
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P2860
Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex
description
2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
@zh-hk
2002年論文
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2002年論文
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2002年论文
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name
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@ast
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@en
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@nl
type
label
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@ast
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@en
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@nl
prefLabel
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@ast
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@en
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@nl
P2860
P356
P1476
Checkpoint protein BubR1 acts ...... bit anaphase-promoting complex
@en
P2093
Guowei Fang
P2860
P304
P356
10.1091/MBC.01-09-0437
P407
P577
2002-03-01T00:00:00Z