Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
about
Bub1 regulates chromosome segregation in a kinetochore-independent mannerMTBP plays a crucial role in mitotic progression and chromosome segregationThe role of aneuploidy in promoting and suppressing tumorsSimian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 bindingWhen 2+2=5: the origins and fates of aneuploid and tetraploid cellsInsights into APC/C: from cellular function to diseases and therapeuticsAurora B hyperactivation by Bub1 overexpression promotes chromosome missegregationChromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomesMouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.Cdc20 is critical for meiosis I and fertility of female miceUSP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesisPhosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshinOverexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemiaInactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferationRole of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesisOsteosarcomagenesis: modeling cancer initiation in the mouse.Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsInterphase cytofission maintains genomic integrity of human cells after failed cytokinesis.Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.PrognoScan: a new database for meta-analysis of the prognostic value of genes.Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.Chromosomal instability confers intrinsic multidrug resistance.BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).Prolactin-induced protein is required for cell cycle progression in breast cancer.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Usp7 protects genomic stability by regulating Bub3.The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesisCdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.Chromosome missegregation causes colon cancer by APC loss of heterozygosity.Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse modelsMicroRNA-450a-3p represses cell proliferation and regulates embryo development by regulating Bub1 expression in mouse.Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationVector design influences hepatic genotoxicity after adeno-associated virus gene therapy.Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viabilityCyclin B2 and p53 control proper timing of centrosome separation
P2860
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P2860
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2007年の論文
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2007年学术文章
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2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
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2007年學術文章
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name
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@ast
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@en
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@nl
type
label
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@ast
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@en
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@nl
prefLabel
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@ast
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@en
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@nl
P2093
P2860
P921
P3181
P356
P1476
Bub1 mediates cell death in re ...... ress spontaneous tumorigenesis
@en
P2093
Darren J Baker
Jan M van Deursen
Karthik Jeganathan
Liviu Malureanu
Susan C Abraham
P2860
P304
P3181
P356
10.1083/JCB.200706015
P407
P577
2007-10-22T00:00:00Z