Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase - Test2 - elhamkhani - TriplyDB

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

http://www.wikidata.org/entity/Q24683942

about

Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1 Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor Mitotic regulation of the human anaphase-promoting complex by phosphorylation Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1 Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes.Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species The roles of cyclin A2, B1, and B2 in early and late mitotic events Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Quantitative framework for ordered degradation of APC/C substrates.Sequential replication-coupled destruction at G1/S ensures genome stability.Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry.Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.Cdc20 is critical for meiosis I and fertility of female mice Foci of cyclin A2 interact with actin and RhoA in mitosis.Spatiotemporal regulation of the anaphase-promoting complex in mitosis The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box Bioluminescence imaging of DNA synthetic phase of cell cycle in living animals G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network.The anaphase promoting complex/cyclosome: a machine designed to destroy A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly.

P2860

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P2860

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

http://www.wikidata.org/entity/Q24683942

description

2001 nî lūn-bûn

@nan

2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2001年の論文

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2001年学术文章

@wuu

2001年学术文章

@zh-cn

2001年学术文章

@zh-hans

2001年学术文章

@zh-my

2001年学术文章

@zh-sg

2001年學術文章

@yue

name

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@ast

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@en

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@nl

type

label

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@ast

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@en

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@nl

prefLabel

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@ast

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@en

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@nl

P1433

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P2860

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P3181

P356

P1433

Journal of Cell Biology

P1476

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

@en

P2093

N den Elzen

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a human mitotic checkpoint gene: hsMAD2

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

Cyclin A is required at two points in the human cell cycle

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

The ubiquitin system

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.

The spindle checkpoint.

P304

121-36

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

904826

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P356

10.1083/JCB.153.1.121

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P407

P433

1

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P478

153

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P50

Jonathon Noe Joseph Pines

P577

2001-04-02T00:00:00Z

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P5875

12049058

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P698

11285279

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P932

2185531

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