An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase - Test2 - elhamkhani - TriplyDB

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

http://www.wikidata.org/entity/Q27662837

about

Specific small molecule inhibitors of Skp2-mediated p27 degradation Bacteria-host relationship: ubiquitin ligases as weapons of invasion Targeting the ubiquitin pathway for cancer treatment Building and remodelling Cullin-RING E3 ubiquitin ligases Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases The acute respiratory distress syndrome: from mechanism to translation An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Twists and turns in ubiquitin-like protein conjugation cascades.Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Induced protein degradation: an emerging drug discovery paradigm.Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer Development of inhibitors in the ubiquitination cascade.Structural regulation of cullin-RING ubiquitin ligase complexes.Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.SCF ubiquitin ligases in the maintenance of genome stability.Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control.Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.Inhibiting the protein ubiquitination cascade by ubiquitin-mimicking short peptides.Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system.The Colossus of ubiquitylation: decrypting a cellular code.Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.The role of allostery in the ubiquitin-proteasome system Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system Targeting ubiquitination for cancer therapies.New insights on the function of SCF ubiquitin E3 ligases in the lung.Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies.Mechanisms and function of substrate recruitment by F-box proteins.The emerging role of the ubiquitin proteasome in pulmonary biology and disease.Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer.Fbw7 dimerization determines the specificity and robustness of substrate degradation.

P2860

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P2860

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

http://www.wikidata.org/entity/Q27662837

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@ast

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@en

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@nl

type

label

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@ast

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@en

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@nl

prefLabel

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@ast

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@en

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@nl

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P2860

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P1433

Nature Biotechnology

P1476

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

@en

P2093

Eric D Brown

http://www.w3.org/2001/XMLSchema#string

Mike Tyers

http://www.w3.org/2001/XMLSchema#string

Nadine Elowe

http://www.w3.org/2001/XMLSchema#string

Stephen Orlicky

http://www.w3.org/2001/XMLSchema#string

Victor Neduva

http://www.w3.org/2001/XMLSchema#string

Xiaojing Tang

http://www.w3.org/2001/XMLSchema#string

P2860

Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis

Phosducin induces a structural change in transducin beta gamma

TOR signaling in growth and metabolism

The ubiquitin system

P2888

P304

733-7

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scholarly article

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10.1038/NBT.1646

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7

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28

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2010-07-01T00:00:00Z

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44803610

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1037502423

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P698

20581844

http://www.w3.org/2001/XMLSchema#string

P921

allosteric inhibitor

P932

4445864

http://www.w3.org/2001/XMLSchema#string