Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α - Test2 - elhamkhani - TriplyDB

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

http://www.wikidata.org/entity/Q27674529

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Targeting Protein-Protein Interactions in the HIF System Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions Targeting the androgen receptor with steroid conjugates Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?Discovery of novel inhibitors disrupting HIF-1α/von Hippel-Lindau interaction through shape-based screening and cascade docking Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition NMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexes Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.Catalytic in vivo protein knockdown by small-molecule PROTACs.Induced protein degradation: an emerging drug discovery paradigm.Nature Biotechnology's academic spinouts of 2013.Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Chemical Methods to Knock Down the Amyloid Proteins.Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.Waste disposal-An attractive strategy for cancer therapy.Targeted protein knockdown using small molecule degraders.Targeted Protein Degradation: from Chemical Biology to Drug Discovery.An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces.Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.An affinity-directed protein missile system for targeted proteolysis.Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-Targeting oncoproteins for degradation by small molecules in myeloid leukemia.Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis.QSAR modeling and in silico design of small-molecule inhibitors targeting the interaction between E3 ligase VHL and HIF-1α.Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition.Worldwide Protein Data Bank validation information: usage and trends.Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

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Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

http://www.wikidata.org/entity/Q27674529

description

2012 nî lūn-bûn

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

@ast

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

@en

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

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type

label

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

@ast

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

@en

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

@nl

prefLabel

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

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Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

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Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

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Angewandte Chemie International Edition

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Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

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Anke G Roth

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Craig M Crews

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Dennis L Buckley

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Hyun Seop Tae

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Jeffrey L Gustafson

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Peter C Gareiss

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P2860

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

Structural conservation of druggable hot spots in protein-protein interfaces

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Structure of the stapled p53 peptide bound to Mdm2

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

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11463-7

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2676699

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10.1002/ANIE.201206231

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46

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51

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William L. Jorgensen

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2012-11-12T00:00:00Z

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232249739

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23065727

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3519281

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