Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
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Structure of an agonist-bound human A2A adenosine receptorAgonist-bound adenosine A2A receptor structures reveal common features of GPCR activationThe structural basis for agonist and partial agonist action on a β(1)-adrenergic receptorDiversity and modularity of G protein-coupled receptor structuresLarge-scale production and protein engineering of G protein-coupled receptors for structural studiesNew insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptorsSingle-cell analysis of G-protein signal transductionStructural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signalingCardiac contractility structure-activity relationship and ligand-receptor interactions; the discovery of unique and novel molecular switches in myosuppressin signalingComputational study on the different ligands induced conformation change of β2 adrenergic receptor-Gs protein complexSearch for β2 adrenergic receptor ligands by virtual screening via grid computing and investigation of binding modes by docking and molecular dynamics simulationsTwo distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptorStructure of the agonist-bound neurotensin receptorBiophysical Fragment Screening of the β 1 -Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug DesignStructural Features for Functional Selectivity at Serotonin ReceptorsCrystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and CarvedilolMolecular control of δ-opioid receptor signallingThe 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free ReceptorFunction-specific virtual screening for GPCR ligands using a combined scoring methodβ2-Adrenergic ion-channel coupled receptors as conformational motion detectorsModeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugsGDP release preferentially occurs on the phosphate side in heterotrimeric G-proteinsMolecular insights into the dynamics of pharmacogenetically important N-terminal variants of the human β2-adrenergic receptor3D structure prediction of human β1-adrenergic receptor via threading-based homology modeling for implications in structure-based drug designingDrug design for ever, from hype to hopeThe Principles of Ligand Specificity on beta-2-adrenergic receptorMembrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes.Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study.Overcoming barriers to membrane protein structure determination.Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins.Compound activity prediction using models of binding pockets or ligand properties in 3D.Docking Screens for Novel Ligands Conferring New Biology.Pathway and mechanism of drug binding to G-protein-coupled receptors.Comparison of dynamics of extracellular accesses to the β(1) and β(2) adrenoceptors binding sites uncovers the potential of kinetic basis of antagonist selectivity.Structure-function of the G protein-coupled receptor superfamily.Structure-based simulations reveal concerted dynamics of GPCR activationLigand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniquesThermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor.Action of molecular switches in GPCRs--theoretical and experimental studies.Exploring binding properties of agonists interacting with a δ-opioid receptor.
P2860
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P2860
Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@ast
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@en
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@nl
type
label
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@ast
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@en
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@nl
prefLabel
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@ast
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@en
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@nl
P2860
P50
P3181
P356
P1476
Conserved Binding Mode of Huma ...... ealed by X-ray Crystallography
@en
P2093
Gustavo Fenalti
Monica A Brown
P2860
P304
P3181
P356
10.1021/JA105108Q
P407
P577
2010-08-25T00:00:00Z