Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
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Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D SuperfamilyTyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Processing of damaged DNA ends for double-strand break repair in mammalian cellsIdentification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assayTyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).DNA repair deficiency in neurodegeneration.Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Structure-function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thalianaSynthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.Repair of topoisomerase I-mediated DNA damage.The involvement of DNA-damage and -repair defects in neurological dysfunctionTyrosyl-DNA phosphodiesterase as a target for anticancer therapyDiscovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft.TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Modulation of DNA base excision repair during neuronal differentiation.SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites.Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin.Development of a high-throughput screening platform for DNA 3'-phosphatases and their inhibitors based on a universal molecular beacon and quantitative real-time PCR.Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II derivatives: a biocatalytic approach.Nucleotide excision repair eliminates unique DNA-protein cross-links from mammalian cells.Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1.The Interaction of the Metallo-Glycopeptide Anti-Tumour Drug Bleomycin with DNA.
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P2860
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
description
2005 nî lūn-bûn
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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@ast
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@en
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@en-gb
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@nl
type
label
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@ast
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@en
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@en-gb
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@nl
prefLabel
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@ast
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@en
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@en-gb
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@nl
P2093
P2860
P356
P1476
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
@en
P2093
Alex B Burgin
Amy C Raymond
Bart L Staker
P2860
P304
P356
10.1074/JBC.M502148200
P407
P577
2005-06-10T00:00:00Z