about
Drugging topoisomerases: lessons and challengesTyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitorsInvolvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B virusesIdentification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assayA New Method, "Reverse Yeast Two-Hybrid Array" (RYTHA), Identifies Mutants that Dissociate the Physical Interaction Between Elg1 and Slx5.Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancerEpigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panelTherapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes.Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Topoisomerase-mediated chromosomal break repair: an emerging player in many games.SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.Targeting DNA repair and replication stress in the treatment of ovarian cancer.Mechanisms of DNA-protein crosslink repair.Xeronine structure and function: computational comparative mastery of its mystery.TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan.AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe.Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents.Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis.The Human Tyrosyl-DNA Phosphodiesterase 1 (hTdp1) Inhibitor NSC120686 as an Exploratory Tool to Investigate Plant Tdp1 Genes.DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors
@ast
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors
@en
type
label
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors
@ast
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors
@en
prefLabel
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors
@ast
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors
@en
P2860
P1476
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors
@en
P2093
Christophe Marchand
Shar-yin N Huang
P2860
P304
P356
10.1517/13543776.2011.604314
P407
P50
P577
2011-09-01T00:00:00Z