Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1) - Test2 - elhamkhani - TriplyDB

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

http://www.wikidata.org/entity/Q24557437

about

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1 Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Processing of damaged DNA ends for double-strand break repair in mammalian cells TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Nonhomologous end joining: a good solution for bad ends Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).DNA repair deficiency in neurodegeneration.Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break.Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Genes and genetic testing in hereditary ataxias.Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).Neurological disorders associated with DNA strand-break processing enzymes.DNA repair mechanisms in dividing and non-dividing cells.Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.Structure-function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.Repair of topoisomerase I-mediated DNA damage.Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.DNA repair deficiency and neurological disease.4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells.Cellular radiosensitivity: how much better do we understand it?To live or to die: a matter of processing damaged DNA termini in neurons.

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Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

http://www.wikidata.org/entity/Q24557437

description

2005 nî lūn-bûn

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2005 թուականին հրատարակուած գիտական յօդուած

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2005 թվականին հրատարակված գիտական հոդված

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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name

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@ast

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@en

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@nl

type

label

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@ast

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@en

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@nl

prefLabel

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@ast

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@en

Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

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Nucleic Acids Research

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Deficiency in 3'-phosphoglycol ...... l-DNA phosphodiesterase (TDP1)

@en

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Haritha Tatavarthi

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Jae Wan Lee

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James R Lupski

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Kristoffer Valerie

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Lawrence F Povirk

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Tong Zhou

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P2860

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

Molecular characterization of a human DNA kinase

DNA end-joining catalyzed by human cell-free extracts

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein.

The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

Regulation and mechanisms of mammalian double-strand break repair

Characterization of the human and mouse WRN 3'-->5' exonuclease

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

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3029928

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10.1093/NAR/GKI170

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1

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33

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8082911

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15647511

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546157

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