Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1
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Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate endsIncreased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancerDeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IVStructure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilumPathways for repairing and tolerating the spectrum of oxidative DNA lesionsAnalysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D SuperfamilyRepair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damageTyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Processing of damaged DNA ends for double-strand break repair in mammalian cellsTDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and IITDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivoDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionDesign and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I.Numt-mediated double-strand break repair mitigates deletions during primate genome evolutionIdentification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assayMitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Nonhomologous end joining: a good solution for bad endsRole of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutationStable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivityTyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break.Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitorsHuman Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).Neurological disorders associated with DNA strand-break processing enzymes.Recognition and repair of chemically heterogeneous structures at DNA endsVariation in base excision repair capacity.Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavageRestoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.
P2860
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P2860
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1
description
2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@ast
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@en
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@en-gb
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@nl
type
label
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@ast
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@en
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@en-gb
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@nl
prefLabel
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@ast
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@en
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@en-gb
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@nl
P2093
P2860
P3181
P356
P1476
Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1
@en
P2093
Aghdass Rasouli-Nia
Jeffrey J Pouliot
Kedar V Inamdar
Lawrence F Povirk
Susan P Lees-Miller
P2860
P304
P3181
P356
10.1074/JBC.M204688200
P407
P577
2002-07-26T00:00:00Z