Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
about
Chk2 activation dependence on Nbs1 after DNA damageThe stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayATMIN defines an NBS1-independent pathway of ATM signallingRegulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbodyHaploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cellsATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damageStructure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the DrawbacksMechanism and regulation of incisions during DNA interstrand cross-link repairTranscriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptationSuppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationAspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATMEDD mediates DNA damage-induced activation of CHK2Genome-wide screen of genes required for caffeine tolerance in fission yeastA high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage responseThe radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathwayp53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaksUV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochoresDetermination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.The nuclear death domain protein p84N5 activates a G2/M cell cycle checkpoint prior to the onset of apoptosis.The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin.Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathwayCaffeine inhibits human immunodeficiency virus type 1 transduction of nondividing cellsInduction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells.Ultrastructural changes associated with the induction of premature chromosome condensation in Vicia faba root meristem cells.Safeguarding entry into mitosis: the antephase checkpoint.The enigmatic effects of caffeine in cell cycle and cancerCaffeine and human DNA metabolism: the magic and the mystery.Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing.Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library.Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase.
P2860
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P2860
Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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name
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@ast
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@en
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@nl
type
label
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@ast
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@en
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@nl
prefLabel
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@ast
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@en
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@nl
P2093
P2860
P3181
P356
P1476
Caffeine abolishes the mammali ...... ctasia-mutated kinase activity
@en
P2093
J D Winkler
K K Khanna
M R Mattern
P Chaturvedi
R A Johanson
P2860
P304
P3181
P356
10.1074/JBC.275.14.10342
P407
P577
2000-04-07T00:00:00Z