Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
about
The Homer family proteinsTranscriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant miceHaploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communicationSurface clustering of metabotropic glutamate receptor 1 induced by long Homer proteinsA screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIIIAssociation of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilamentsLong-Term Potentiation and MemorySPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampusA prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitizationA novel association of mGluR1a with the PDZ scaffold protein CAL modulates receptor activityImportance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsSynaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disordersMultiple rare variants in the etiology of autism spectrum disordersThe postsynaptic density proteins Homer and Shank form a polymeric network structureGlutamatergic substrates of drug addiction and alcoholismThe neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cellsCortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neuronsBehavioral phenotypes of genetic mouse models of autism.Cellular and synaptic network defects in autismRole of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunityTwo knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Homer1/mGluR5 activity moderates vulnerability to chronic social stressAltered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairmentDiscovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domainGenetic aspects of autism spectrum disorders: insights from animal modelsmGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons.A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthaseThe calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteinsThe Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein HomerPI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosisPDZ domains: structural modules for protein complex assemblyThe actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7
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P2860
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@ast
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@en
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@nl
type
label
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@ast
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@en
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@nl
prefLabel
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@ast
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@en
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@nl
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P1476
Coupling of mGluR/Homer and PS ...... postsynaptic density proteins
@en
P2093
A A Lanahan
P Brakeman
P F Worley
R S Petralia
S Naisbitt
P304
P3181
P356
10.1016/S0896-6273(00)80810-7
P407
P577
1999-07-01T00:00:00Z