Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity
about
sameAs
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinCharacterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cellsCdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin bindingHuman geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosisPrevention of DNA re-replication in eukaryotic cellsPreventing re-replication of chromosomal DNA.Functional domains of the Xenopus replication licensing factor Cdt1Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extractsMechanisms for initiating cellular DNA replicationStructure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factorsStructure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm ProteinsThe Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication LicensingRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityHBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by GemininHelicase loading at chromosomal origins of replicationStructural basis for inhibition of the replication licensing factor Cdt1 by gemininChromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.Origin licensing and p53 status regulate Cdk2 activity during G(1).Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.Structural insights into the Cdt1-mediated MCM2-7 chromatin loading.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Geminin inhibits a late step in the formation of human pre-replicative complexes.Replication licensing and the DNA damage checkpoint.DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cellsMultiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicasesEukaryotic MCM proteins: beyond replication initiation.Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value.An inactive geminin mutant that binds cdt1Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.NF-kappaB and Snail1a coordinate the cell cycle with gastrulationGeminin is partially localized to the centrosome and plays a role in proper centrosome duplication.Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.DnaA, ORC, and Cdc6: similarity beyond the domains of life and diversity.Flipping the switch from g1 to s phase with e3 ubiquitin ligasesRegulating DNA replication in eukarya.FUCCI sensors: powerful new tools for analysis of cell proliferation.
P2860
Q24298173-38CF4E0B-2EF8-43C6-B586-62E22E1EBAA2Q24301640-ED3B8B4D-BD2C-4A2F-BBA1-DA59BB162687Q24301758-74FD2D5C-8A99-4C55-BF57-68839D3342E0Q24313280-CA4C33A5-5DD9-40D4-A5BA-7797B7B28E9EQ24563189-0C16E20F-2464-4F74-B3B6-B943190BE577Q24632601-9A72C833-77F3-4117-B109-E89AF0DAD4CBQ24653685-5F397348-A44F-47FA-A2B8-584F0A70CFA3Q24794160-6FD35175-3EA8-4D90-9FD5-0DA7EE858CB9Q24802342-A7D0D2A2-D617-4FDB-8464-2A869B01A80DQ26827264-DDB71AFF-0008-4D7E-89E1-F4AB11865481Q27657263-0DC811C9-56AC-452E-A3BD-4A614F8796D4Q27660318-DCAF4539-CA52-4091-98A6-5F2792E934D1Q27680038-92281FCA-85E3-49FB-A174-E830D06F9FC7Q28068574-5D1600F1-6737-4434-BC61-177F73108809Q28272275-1AB50E4C-66E1-4AF3-8CE3-98407A96D227Q28289537-3A2BD214-F80E-4371-92D9-715DE5A3B376Q28587164-B186180E-9152-461C-BF45-803CE4BBF16AQ30429899-990D3335-A49F-4F92-B3D1-39EA5D580E6CQ30434208-318867F9-1E1F-4462-88DB-CF012FBF0586Q33712618-99CCD7BF-0F95-4436-9CBB-C7D07AC2FFD3Q34090656-E379F257-985D-4F90-9254-2D38CD80D7FCQ34249169-DCAAB79F-2B43-4E5B-AD9E-2CA7C58E1205Q34431115-B542BE3E-5BA9-4DC8-A632-5604CC8E724DQ34547673-8BA14609-09A9-46CF-9341-855E937DC87CQ35176517-CBB1F26D-9727-480B-A931-686F8CB8CB0EQ35222221-63A7ECAE-9E8F-4C70-9A16-38D78435E037Q35558059-E1F0C0A2-104B-49F8-B9D4-24254DFAB850Q35626395-2C9E7E00-49FB-4FFB-BE6E-6F58427E1CD2Q35684975-8F7D9920-29C7-4E94-91A0-74CAF8DC0E18Q35709269-88BD27DB-8A19-47D7-8158-D51205E6B1B6Q35808481-36D032AF-E63E-462E-9EF1-5CCC54217CD8Q36489137-27A49A29-5362-49DA-89A3-DB1E3DF4CAF9Q36956930-0D8BBF87-FA24-4644-9AAE-A30AE6CC2613Q37234336-8CDEB8E5-6E51-4487-88AD-1374BB4B92DAQ37434334-A9C1EDBB-C72B-4457-B889-E1935BE05D6DQ37447957-CAC29779-1C89-4E70-94CA-3C0A194BFC10Q37687102-F812B0A8-0750-4843-BCFA-60BEFBFE5F7DQ38103251-D47D231F-5F6D-4D91-89AE-1498D880A9DAQ38120365-0E53111D-55B7-499C-B298-FB11D89C8299Q38397620-3A35C35F-0B43-4DDC-B673-C489B3C2DC68
P2860
Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@ast
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@en
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@nl
type
label
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@ast
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@en
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@nl
prefLabel
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@ast
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@en
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@nl
P2093
P2860
P921
P356
P1476
Mouse geminin inhibits not onl ...... nsic Cdt1 DNA binding activity
@en
P2093
Fumio Hanaoka
Ken-ichiro Yanagi
Takeshi Mizuno
Zhiying You
P2860
P304
P356
10.1074/JBC.M206202200
P407
P577
2002-10-25T00:00:00Z