Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa - Test2 - elhamkhani - TriplyDB

Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa

Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa

http://www.wikidata.org/entity/Q28259620

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Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells The Bcl-2 apoptotic switch in cancer development and therapy The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells The role of HTS in drug discovery at the University of Michigan.Extracts from Cladiella australis, Clavularia viridis and Klyxum simplex (soft corals) are capable of inhibiting the growth of human oral squamous cell carcinoma cells Proteasome inhibitor MG132 inhibits the proliferation and promotes the cisplatin-induced apoptosis of human esophageal squamous cell carcinoma cells.Large-scale analysis of UPR-mediated apoptosis in human cells.Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway.Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition.The ubiquitin-proteasome system: opportunities for therapeutic intervention in solid tumors Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.Down-regulation of 11β-hydroxysteroid dehydrogenase type 2 by bortezomib sensitizes Jurkat leukemia T cells against glucocorticoid-induced apoptosis.Cantharidins induce ER stress and a terminal unfolded protein response in OSCC.Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy.The 26S proteasome complex: an attractive target for cancer therapy SEL1L, an UPR response protein, a potential marker of colonic cell transformation Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.Noxa/Mcl-1 balance regulates susceptibility of cells to camptothecin-induced apoptosis.Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.Proteasome inhibition and allogeneic hematopoietic stem cell transplantation: a review Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition.Lower expression of activating transcription factors 3 and 4 correlates with shorter progression-free survival in multiple myeloma patients receiving bortezomib plus dexamethasone therapy.Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.Proteasome Inhibitor YSY01A Enhances Cisplatin Cytotoxicity in Cisplatin-Resistant Human Ovarian Cancer Cells.Phosphorylation of signal transducer and activator of transcription 1 reduces bortezomib-mediated apoptosis in cancer cells.Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.Phase I study of bortezomib and cetuximab in patients with solid tumours expressing epidermal growth factor receptor.Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1 Old target new approach: an alternate NF-kappaB activation pathway via translation inhibition.Post-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells.Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part II: targeting cell cycle events, caspases, NF-κB and the proteasome.The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy Synergistic effects of cisplatin and proteasome inhibitor bortezomib on human bladder cancer cells.Ricolinostat (ACY-1215) induced inhibition of aggresome formation accelerates carfilzomib-induced multiple myeloma cell death.Review and Literature Mining on Proteostasis Factors and Cancer.Carfilzomib and oprozomib synergize with histone deacetylase inhibitors in head and neck squamous cell carcinoma models of acquired resistance to proteasome inhibitors.Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer.

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P2860

Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa

http://www.wikidata.org/entity/Q28259620

description

2006 nî lūn-bûn

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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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Proteasome inhibitor PS-341 in ...... oma cells by induction of Noxa

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Proteasome inhibitor PS-341 in ...... oma cells by induction of Noxa

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Proteasome inhibitor PS-341 in ...... oma cells by induction of Noxa

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Proteasome inhibitor PS-341 in ...... oma cells by induction of Noxa

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Proteasome inhibitor PS-341 in ...... oma cells by induction of Noxa

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Proteasome inhibitor PS-341 in ...... oma cells by induction of Noxa

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Andrew M Fribley

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Bae Keun Park

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Benjamin Evenchik

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Cun-Yu Wang

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Honglai Zhang

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Jean Y Guan

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Maria S Soengas

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Qinghua Zeng

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Randal J Kaufman

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Timothy J Hale

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P2860

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

Human caspase 12 has acquired deleterious mutations

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

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1015890

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10.1074/JBC.M604356200

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42

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281

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16928686

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