Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
about
The spectrum of SWI/SNF mutations, ubiquitous in human cancersResidual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutationTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyTargeting LKB1 in cancer - exposing and exploiting vulnerabilitiesATP-dependent chromatin remodeling complexes as novel targets for cancer therapySWI/SNF chromatin remodeling complexes and cancerSWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functionsDeletion of Brg1 causes abnormal hair cell planer polarity, hair cell anchorage, and scar formation in mouse cochleaSMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung CancerComprehensive molecular profiling of lung adenocarcinoma.The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancerSWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2The SWI/SNF genetic blockade: effects in cell differentiation, cancer and developmental diseasesFrequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinomaFrom Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical ResearchSMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancersSomatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencingThe SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell ProliferationGermline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome.Molecular pathways and therapeutic targets in lung cancerDOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.BRG1 promotes hepatocarcinogenesis by regulating proliferation and invasivenessChromatin-regulating proteins as targets for cancer therapy.A gene-alteration profile of human lung cancer cell lines.A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene.Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.Flavonoids from each of the six structural groups reactivate BRM, a possible cofactor for the anticancer effects of flavonoidsMechanisms by which SMARCB1 loss drives rhabdoid tumor growth.Mutational analysis reveals the origin and therapy-driven evolution of recurrent gliomaEZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.Improving accuracy for cancer classification with a new algorithm for genes selection.BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells.Insertion/deletion polymorphisms in the promoter region of BRM contribute to risk of hepatocellular carcinoma in Chinese populations.Simultaneous identification of multiple driver pathways in cancerMutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma.Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?Expression inactivation of SMARCA4 by microRNAs in lung tumorsFunctional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.
P2860
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P2860
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@ast
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@en
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@nl
type
label
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@ast
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@en
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@nl
prefLabel
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@ast
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@en
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@nl
P2093
P3181
P356
P1433
P1476
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
@en
P2093
Jun Yokota
Luis M Montuenga
Montse Sanchez-Cespedes
Octavio A Romero
Pedro P Medina
Takashi Kohno
P304
P3181
P356
10.1002/HUMU.20730
P407
P577
2008-05-01T00:00:00Z