Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.
about
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genesInteraction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase IICDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsMutual relationships between transcription and pre-mRNA processing in the synthesis of mRNAIntegrated genomic analyses of ovarian carcinomaA functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in DrosophilaCyclin-dependent kinases: a family portrait.The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing.Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migrationCharacterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.A partial form of recessive STAT1 deficiency in humans.Ectopic expression of nolz-1 in neural progenitors promotes cell cycle exit/premature neuronal differentiation accompanying with abnormal apoptosis in the developing mouse telencephalon.Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processingMislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer diseaseOvarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.Control of alternative pre-mRNA splicing by Ca(++) signals.TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization.GADD45α and γ interaction with CDK11p58 regulates SPDEF protein stability and SPDEF-mediated effects on cancer cell migrationCdk12 is essential for embryonic development and the maintenance of genomic stability.Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitorsAssociation of two synonymous splicing-associated CpG single nucleotide polymorphisms in calpain 10 and solute carrier family 2 member 2 with type 2 diabetesCyclin K goes with Cdk12 and Cdk13Ovarian epithelial tumors and reproductive factors: a systematic review.Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II.The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1.Inhibitors of cyclin-dependent kinases as cancer therapeutics.Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework.CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing.CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.Updating the CTD Story: From Tail to Epic.The role for CYCLIN A1;2/TARDY ASYNCHRONOUS MEIOSIS in differentiated cells in Arabidopsis.The cyclin K/Cdk12 complex: an emerging new player in the maintenance of genome stability.The cyclin L homolog MOS12 and the MOS4-associated complex are required for the proper splicing of plant resistance genes.The emerging roles of CDK12 in tumorigenesis.Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.CYCLIN-DEPENDENT KINASE G1 is associated with the spliceosome to regulate CALLOSE SYNTHASE5 splicing and pollen wall formation in Arabidopsis.
P2860
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P2860
Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Identification and characteriz ...... lternative splicing regulation
@nl
Identification and characteriz ...... ternative splicing regulation.
@ast
Identification and characteriz ...... ternative splicing regulation.
@en
type
label
Identification and characteriz ...... lternative splicing regulation
@nl
Identification and characteriz ...... ternative splicing regulation.
@ast
Identification and characteriz ...... ternative splicing regulation.
@en
prefLabel
Identification and characteriz ...... lternative splicing regulation
@nl
Identification and characteriz ...... ternative splicing regulation.
@ast
Identification and characteriz ...... ternative splicing regulation.
@en
P2093
P2860
P1476
Identification and characteriz ...... ternative splicing regulation.
@en
P2093
Hung-Hsi Chen
Ming-Ji Fann
Yu-Chiuan Wang
P2860
P304
P356
10.1128/MCB.26.7.2736-2745.2006
P407
P577
2006-04-01T00:00:00Z