Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
about
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylationSestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor αRole of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacksSestrins at the crossroad between stress and agingConserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingLong live FOXO: unraveling the role of FOXO proteins in aging and longevityHormonal Regulation of Response to Oxidative Stress in Insects-An UpdateSestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose TissueMAPK/JNK signalling: a potential autophagy regulation pathwayFOXO transcription factors: key regulators of cellular quality controlCellular and molecular mechanisms of muscle atrophyThe role of tumor suppressor p53 in the antioxidant defense and metabolismRecent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domainsHepatoprotective role of Sestrin2 against chronic ER stressSestrins inhibit mTORC1 kinase activation through the GATOR complexSestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signalingThe CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayProteotoxicity: an underappreciated pathology in cardiac diseaseOxidative stress and autophagy: the clash between damage and metabolic needsMaintenance of metabolic homeostasis by Sestrin2 and Sestrin3Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signalingIdentification of Sestrin3 Involved in the In vitro Resistance of Colorectal Cancer Cells to IrinotecanRegulation of the mTOR complex 1 pathway by nutrients, growth factors, and stressObesity-associated cardiac dysfunction in starvation-selected Drosophila melanogasterSesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3.High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in DrosophilaDominant negative inhibition data should be analyzed using mathematical modeling--re-interpreting data from insulin signaling.Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation.Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila.Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation.Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.Wolbachia infections in Anopheles gambiae cells: transcriptomic characterization of a novel host-symbiont interaction.The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injurySestrin2 Suppresses Classically Activated Macrophages-Mediated Inflammatory Response in Myocardial Infarction through Inhibition of mTORC1 Signaling.Paradoxical suppression of cellular senescence by p53MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
P2860
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P2860
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
description
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 2010
@ast
im März 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/03/05)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/03/05)
@nl
наукова стаття, опублікована в березні 2010
@uk
name
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@ast
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@en
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@nl
type
label
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@ast
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@en
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@nl
prefLabel
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@ast
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@en
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
@en
P2093
Andrei V. Budanov
Eek Joong Park
Ethan Bier
Guy A. Perkins
Jun Hee Lee
Karen Ocorr
Mark H. Ellisman
Rolf Bodmer
Ryan Birse
Teddy E. Kim
P2860
P304
P3181
P356
10.1126/SCIENCE.1182228
P407
P577
2010-03-05T00:00:00Z