Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway - Test2 - elhamkhani - TriplyDB

Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway

Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway

http://www.wikidata.org/entity/Q28590671

about

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.The N-end rule pathway Discovery of cellular regulation by protein degradation Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway Structural basis of substrate recognition and specificity in the N-end rule pathway Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination The substrate recognition domains of the N-end rule pathway.Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population.PINK1 is degraded through the N-end rule pathway Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome RGS4 and RGS5 are in vivo substrates of the N-end rule pathway The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein The Ubr2 Gene is Expressed in Skeletal Muscle Atrophying as a Result of Hind Limb Suspension, but not Merg1a Expression Alone The N-end rule pathway and regulation by proteolysis UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.Dissection of c-MOS degron Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.The ChIP-seq-defined networks of Bcl-3 gene binding support its required role in skeletal muscle atrophy.Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.Meiotic functions of RAD18.Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes Molecular and cellular mechanisms of skeletal muscle atrophy: an update.Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications.UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.Roles and potential therapeutic targets of the ubiquitin proteasome system in muscle wasting.The N-end rule and retroviral infection: no effect on integrase.Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin- dependent N-end rule pathway.Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks.Deubiquitinases in skeletal muscle atrophy.Mutations in the human UBR1 gene and the associated phenotypic spectrum.

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P2860

Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway

http://www.wikidata.org/entity/Q28590671

description

2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2001

@ast

im Dezember 2001 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2001/12/01)

@sk

vědecký článek publikovaný v roce 2001

@cs

wetenschappelijk artikel (gepubliceerd op 2001/12/01)

@nl

наукова стаття, опублікована в грудні 2001

@uk

مقالة علمية (نشرت في ديسمبر 2001)

@ar

name

Construction and analysis of m ...... pha) of the N-end rule pathway

@ast

Construction and analysis of m ...... pha) of the N-end rule pathway

@en

Construction and analysis of m ...... pha) of the N-end rule pathway

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type

label

Construction and analysis of m ...... pha) of the N-end rule pathway

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Construction and analysis of m ...... pha) of the N-end rule pathway

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Construction and analysis of m ...... pha) of the N-end rule pathway

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prefLabel

Construction and analysis of m ...... pha) of the N-end rule pathway

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Construction and analysis of m ...... pha) of the N-end rule pathway

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Construction and analysis of m ...... pha) of the N-end rule pathway

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MCB.21.23.8007-8021.2001

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Molecular and Cellular Biology

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Construction and analysis of m ...... pha) of the N-end rule pathway

@en

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A. Varshavsky

http://www.w3.org/2001/XMLSchema#string

I. V. Davydov

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S. H. Lecker

http://www.w3.org/2001/XMLSchema#string

Y. T. Kwon

http://www.w3.org/2001/XMLSchema#string

Z. Xia

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P2860

Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6

The N-end rule: functions, mysteries, uses

The mouse and human genes encoding the recognition component of the N-end rule pathway

The ubiquitin system

Ubiquitin-dependent protein degradation

A proteolytic pathway that recognizes ubiquitin as a degradation signal.

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.

The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor

Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway.

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8007–8021

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10.1128/MCB.21.23.8007-8021.2001

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Ubiquitin protein ligase E3 component n-recognin 1

Ubiquitin protein ligase E3 component n-recognin 2

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99968

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