Pocketome via comprehensive identification and classification of ligand binding envelopes.
about
Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignmentStructural conservation of druggable hot spots in protein-protein interfacesSmall molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregatesStructural biology and chemistry of protein arginine methyltransferasesExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsStructural genomics of protein phosphatasesMinimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase InhibitorsStructural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug targetA Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational StatesAssessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug TargetFunctional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIVHigh-resolution structure of the M14-type cytosolic carboxypeptidase fromBurkholderia cenocepaciarefined exploitingPDB_REDOstrategiesPredicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structureA computational approach to finding novel targets for existing drugsExploring the landscape of protein-ligand interaction energy using probabilistic approachTyrosine kinase syk non-enzymatic inhibitors and potential anti-allergic drug-like compounds discovered by virtual and in vitro screeningIn silico assessment of potential druggable pockets on the surface of α1-antitrypsin conformersWhat can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics?Knowledge-based fragment binding predictionIn silico screening for novel inhibitors of DNA polymerase III alpha subunit of Mycobacterium tuberculosis (MtbDnaE2, H37Rv)To Hit or Not to Hit, That Is the Question - Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa ProteinsEmerging Computational Methods for the Rational Discovery of Allosteric Drugs.A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sitesPocketPicker: analysis of ligand binding-sites with shape descriptors.A simple method for finding a protein's ligand-binding pockets.Geometrical comparison of two protein structures using Wigner-D functions.Method for comparing the structures of protein ligand-binding sites and application for predicting protein-drug interactions.DEPTH: a web server to compute depth and predict small-molecule binding cavities in proteinsThe second extracellular loop of the adenosine A1 receptor mediates activity of allosteric enhancersTackling the challenges posed by target flexibility in drug design.GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex.Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activityHomology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complexFlexibility and binding affinity in protein-ligand, protein-protein and multi-component protein interactions: limitations of current computational approaches.Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugsFragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques.Fpocket: an open source platform for ligand pocket detection.Gel-Based Purification and Biochemical Study of Laccase Isozymes from Ganoderma sp. and Its Role in Enhanced Cotton Callogenesis
P2860
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P2860
Pocketome via comprehensive identification and classification of ligand binding envelopes.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Pocketome via comprehensive id ...... n of ligand binding envelopes.
@ast
Pocketome via comprehensive id ...... n of ligand binding envelopes.
@en
type
label
Pocketome via comprehensive id ...... n of ligand binding envelopes.
@ast
Pocketome via comprehensive id ...... n of ligand binding envelopes.
@en
prefLabel
Pocketome via comprehensive id ...... n of ligand binding envelopes.
@ast
Pocketome via comprehensive id ...... n of ligand binding envelopes.
@en
P2860
P1476
Pocketome via comprehensive id ...... n of ligand binding envelopes.
@en
P2093
Jianghong An
Maxim Totrov
P2860
P304
P356
10.1074/MCP.M400159-MCP200
P577
2005-03-09T00:00:00Z