Structural effects of Parkinson's disease linked DJ-1 mutations.
about
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicityGenetics of Parkinson's diseaseConservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimersEngineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.Effect of single amino acid substitution on oxidative modifications of the Parkinson's disease-related protein, DJ-1The genetics of Parkinson disease.A role for the Parkinson's disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus.The role of cysteine oxidation in DJ-1 function and dysfunction.A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine ReuptakeDopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature.Rapid profiling of disease alleles using a tunable reporter of protein misfolding.Private rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis.Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's diseaseIncreased DJ-1 expression under oxidative stress and in Alzheimer's disease brains.Mortalin, apoptosis, and neurodegeneration.The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity.DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells.Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction.Scop3D: three-dimensional visualization of sequence conservation.Intracellular metal binding and redox behavior of human DJ-1.Regulation of Signal Transduction by DJ-1.Structural Biology of the DJ-1 Superfamily.DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals.Structural Characterization of the FlmC Protein Involved in Biofilm Formation
P2860
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P2860
Structural effects of Parkinson's disease linked DJ-1 mutations.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural effects of Parkinson's disease linked DJ-1 mutations.
@ast
Structural effects of Parkinson's disease linked DJ-1 mutations.
@en
type
label
Structural effects of Parkinson's disease linked DJ-1 mutations.
@ast
Structural effects of Parkinson's disease linked DJ-1 mutations.
@en
prefLabel
Structural effects of Parkinson's disease linked DJ-1 mutations.
@ast
Structural effects of Parkinson's disease linked DJ-1 mutations.
@en
P2860
P356
P1433
P1476
Structural effects of Parkinson's disease linked DJ-1 mutations.
@en
P2093
David Eliezer
P2860
P304
P356
10.1110/PS.073411608
P577
2008-05-01T00:00:00Z