Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism - Test2 - elhamkhani - TriplyDB

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

http://www.wikidata.org/entity/Q24797276

about

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1 DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway Human DJ-1 and its homologs are novel glyoxalases Mitochondrial localization of DJ-1 leads to enhanced neuroprotection DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.Molecules that cause or prevent Parkinson's disease The associations between Parkinson's disease and cancer: the plot thickens Genetically engineered mouse models of Parkinson's disease Evolutionary history of a mosquito endosymbiont revealed through mitochondrial hitchhiking Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance Phylogenomic evidence for a common ancestor of mitochondria and the SAR11 clade Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis Symbiosis as an adaptive process and source of phenotypic complexity Structural effects of Parkinson's disease linked DJ-1 mutations.DJ-1 Is Upregulated in Oral Squamous Cell Carcinoma and Promotes Oral Cancer Cell Proliferation and Invasion Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.Genetic mouse models of parkinsonism: strengths and limitations.Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice.Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.DJ-1 contributes to adipogenesis and obesity-induced inflammation.DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling.Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2 Differentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophila.Crystallization and preliminary X-ray data analysis of a DJ-1 homologue from Arabidopsis thaliana (AtDJ-1D).DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.

P2860

Q21146396-2B771649-FD1C-432F-8FEF-697BD03ECFCE Q24296667-87A3B1FD-06AC-47C0-8453-F83D4C35EC4E Q24306270-90A20002-C24B-422D-8BA9-E9414197D926 Q24307823-0FF7433E-FBDC-40BA-9E06-806A4CA5DD16 Q24309004-3A6DEC05-8417-4EF5-BF01-A284020DBDA8 Q24312506-0F2A0903-1ADC-4D8C-83F8-C1FF50E67D67 Q24316421-AB122DCB-443D-46BE-BD0A-02536925A571 Q24324226-9F81C59E-35BF-49F7-A2E2-A578EAA6C8CB Q24338249-B25E84BB-C9DA-4836-B3B4-4535D4424265 Q24339442-E8F0BB5A-F9DB-48A2-A240-66EC9B575BE8 Q24541479-FF3039E4-70C9-47B6-8CC9-5E78648E5FCE Q24793714-3C6EE5FF-EFE7-4A50-AFA5-BCC5224EFAC5 Q26778641-A5693F5F-3CA7-4C54-9795-3E9E7B510A77 Q26852964-37B32147-9F2F-40FC-B515-757B77CAD062 Q27477593-ED3E75A7-6D20-4262-BDF7-85F87B9DB2EA Q27683814-15BDABB7-8F2E-4724-97A1-87804C6F87BC Q28077356-5AD71343-2836-4F05-96A0-EA4EAD482467 Q28260462-E4E1EEA8-FCDF-48D8-9354-EF12872DFA3C Q28480475-8E38EABC-972B-476A-92B8-9B82192DBD61 Q28506366-12963556-86B8-45AA-AD03-5BB77A3D3263 Q28507691-16C90542-E670-46DC-8D9F-570DBFC36678 Q28534455-925737AD-184A-4A63-8CC4-ECD62ED9A8A6 Q28588841-82A81456-0DCA-4138-B8F4-96CCD1298E83 Q28592872-221AD204-C7FC-4256-84AA-71347821B4BF Q28757671-4120EB30-24DA-4D07-9069-03E37B1A28E4 Q30369057-9B897B1D-C003-4C72-9CB5-24279C80585B Q30381288-9105F465-C625-4992-B8BD-663EEEC17E60 Q30481530-D95E2C2F-6339-421A-A15E-10E9B88BFCF7 Q30537732-AC32F79D-1DAF-49E8-99BA-0C46EBF71C7C Q30544278-4BC13635-3609-4E7C-84BA-31350C18CC41 Q33390827-1F6E5323-FA94-44A4-8A16-FCDFA65D6D94 Q33613170-F911E6BC-975D-4EAA-9E3D-A0EEB783213B Q33734076-0272D6C4-4669-41A8-B653-C20CFE5B9B9A Q33749501-4F9280AF-15AF-42A0-8D23-9DB2A468F9EA Q33905966-A6F07266-93F7-4726-8691-92497A9368D7 Q34015950-EC5949A4-AD8B-49C4-8812-1CB0DA99BCC5 Q34056577-34E01FCF-21BE-4206-8F03-E06DFC841B84 Q34092616-1BE89B20-3219-4146-A20E-6A6FF3AEE942 Q34122515-E326237E-6A6E-43DA-9BEB-B995744DF207 Q34166108-AE3386CE-072E-41CA-8951-F30360CE3F77

P2860

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

http://www.wikidata.org/entity/Q24797276

description

2004 nî lūn-bûn

@nan

2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@ast

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@en

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@nl

type

label

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@ast

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@en

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@nl

prefLabel

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@ast

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@en

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@nl

P1433

Q24797276-30F3799E-8554-4430-A579-710CB6C0D0BC

P1476

Q24797276-3C1CD321-3E7D-4ED9-A9B3-151625B4259B

P2093

Q24797276-0190CF21-6C50-40E3-9AE3-E40FE6F69326

Q24797276-16D97816-5885-426B-9489-447C60546347

Q24797276-2BE35529-164D-4311-A757-2B422B6FF16C

Q24797276-4815111A-B02C-4BF0-A50D-A36B39A04478

Q24797276-5B6B0830-5B3F-4C76-BD17-71DD5E22C4D4

Q24797276-9B9B71A3-54C4-46A1-A203-D85E0122C40B

Q24797276-B2149334-340E-49D5-83D2-5DCD04C8072F

Q24797276-C30092C6-0876-4947-8401-BF3E37FCE60A

P2860

Q24797276-03F3D376-BE98-4EBD-A661-57389A793714

Q24797276-05BCB71F-2532-4F4D-8BAE-2941E1B0679D

Q24797276-08601322-A268-45E1-B3D7-7C2FFB8C210B

Q24797276-16EF4DFF-53C6-4D9D-9AA6-CA1925E35345

Q24797276-1A0ECE5C-9EE3-480C-88C5-514300D6B7CC

Q24797276-1A675848-60FA-45DA-BF9A-6BC0F1868E28

Q24797276-29630D7D-6192-4A70-8078-DC95DA497BE1

Q24797276-2BE684AD-9FC1-42E9-8A47-80C6D669EF2D

Q24797276-3A20CF07-8D3F-4033-AFE8-FDD30CD9256C

Q24797276-3A8E22BE-A720-4B8C-84D6-AC9193571644

P304

Q24797276-89996BDE-3D3D-4D65-87AD-5F10C72EAE80

P31

Q24797276-66703B1F-FDDF-4B94-A16D-04E7E10FEE08

P3181

Q24797276-1161930E-D811-461F-AE5B-A2862D0D51F4

P356

Q24797276-45F68D05-0AE9-44F7-8E58-A1F8E06DD1BD

P407

Q24797276-B2D114AE-53BF-47D2-A32C-05A583ADA3DB

P433

Q24797276-2229EA59-BA33-4935-8070-4AB82988D166

P478

Q24797276-834FB87D-B090-4A2D-8A64-2E0C6B9835A1

P577

Q24797276-C7E17E73-DD6C-47AB-9C8F-D34FBB2F9F38

P5875

Q24797276-93022625-E9EC-4876-B239-796BEA760C96

P698

Q24797276-910FABF4-6C46-427F-A946-85AE1360DC6B

P921

Q24797276-0f4ef9c8-70ac-455c-a442-6554fd5e0261

Q24797276-DBC23A06-E318-4310-85AD-DCFB80921ECB

P932

Q24797276-7F3F0C8A-E5B3-4436-8874-0D6493F8B29B

P3181

P356

JOURNAL.PBIO.0020327

P1433

P1476

Sensitivity to oxidative stres ...... model of primary Parkinsonism

@en

P2093

Alan Jonason

http://www.w3.org/2001/XMLSchema#string

Asa Abeliovich

http://www.w3.org/2001/XMLSchema#string

Cecile Martinat

http://www.w3.org/2001/XMLSchema#string

Lichuan Yang

http://www.w3.org/2001/XMLSchema#string

M Flint Beal

http://www.w3.org/2001/XMLSchema#string

Shoshana Shendelman

http://www.w3.org/2001/XMLSchema#string

Thomas Floss

http://www.w3.org/2001/XMLSchema#string

Thomas Leete

http://www.w3.org/2001/XMLSchema#string

P2860

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

DJ-1 has a role in antioxidative stress to prevent cell death

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae.

Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

P304

e327

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1385437

http://www.w3.org/2001/XMLSchema#string

P356

10.1371/JOURNAL.PBIO.0020327

http://www.w3.org/2001/XMLSchema#string

P407

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

2

http://www.w3.org/2001/XMLSchema#string

P577

2004-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8214045

http://www.w3.org/2001/XMLSchema#string

P698

15502868

http://www.w3.org/2001/XMLSchema#string

P921

Parkinson's disease

P932

521171

http://www.w3.org/2001/XMLSchema#string