Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism
about
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formationParkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicityInteraction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell deathDJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaBOxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1DJ-1 induces thioredoxin 1 expression through the Nrf2 pathwayHuman DJ-1 and its homologs are novel glyoxalasesMitochondrial localization of DJ-1 leads to enhanced neuroprotectionDJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factorStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionCooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.Molecules that cause or prevent Parkinson's diseaseThe associations between Parkinson's disease and cancer: the plot thickensGenetically engineered mouse models of Parkinson's diseaseEvolutionary history of a mosquito endosymbiont revealed through mitochondrial hitchhikingUse of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimersGenetics in Parkinson disease: Mendelian versus non-Mendelian inheritancePhylogenomic evidence for a common ancestor of mitochondria and the SAR11 cladeGenotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tauDJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-MycAge-dependent motor deficits and dopaminergic dysfunction in DJ-1 null miceDJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS productionPark7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsisSymbiosis as an adaptive process and source of phenotypic complexityStructural effects of Parkinson's disease linked DJ-1 mutations.DJ-1 Is Upregulated in Oral Squamous Cell Carcinoma and Promotes Oral Cancer Cell Proliferation and InvasionProgressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.Genetic mouse models of parkinsonism: strengths and limitations.Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice.Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.DJ-1 contributes to adipogenesis and obesity-induced inflammation.DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling.Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2Differentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophila.Crystallization and preliminary X-ray data analysis of a DJ-1 homologue from Arabidopsis thaliana (AtDJ-1D).DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.
P2860
Q21146396-2B771649-FD1C-432F-8FEF-697BD03ECFCEQ24296667-87A3B1FD-06AC-47C0-8453-F83D4C35EC4EQ24306270-90A20002-C24B-422D-8BA9-E9414197D926Q24307823-0FF7433E-FBDC-40BA-9E06-806A4CA5DD16Q24309004-3A6DEC05-8417-4EF5-BF01-A284020DBDA8Q24312506-0F2A0903-1ADC-4D8C-83F8-C1FF50E67D67Q24316421-AB122DCB-443D-46BE-BD0A-02536925A571Q24324226-9F81C59E-35BF-49F7-A2E2-A578EAA6C8CBQ24338249-B25E84BB-C9DA-4836-B3B4-4535D4424265Q24339442-E8F0BB5A-F9DB-48A2-A240-66EC9B575BE8Q24541479-FF3039E4-70C9-47B6-8CC9-5E78648E5FCEQ24793714-3C6EE5FF-EFE7-4A50-AFA5-BCC5224EFAC5Q26778641-A5693F5F-3CA7-4C54-9795-3E9E7B510A77Q26852964-37B32147-9F2F-40FC-B515-757B77CAD062Q27477593-ED3E75A7-6D20-4262-BDF7-85F87B9DB2EAQ27683814-15BDABB7-8F2E-4724-97A1-87804C6F87BCQ28077356-5AD71343-2836-4F05-96A0-EA4EAD482467Q28260462-E4E1EEA8-FCDF-48D8-9354-EF12872DFA3CQ28480475-8E38EABC-972B-476A-92B8-9B82192DBD61Q28506366-12963556-86B8-45AA-AD03-5BB77A3D3263Q28507691-16C90542-E670-46DC-8D9F-570DBFC36678Q28534455-925737AD-184A-4A63-8CC4-ECD62ED9A8A6Q28588841-82A81456-0DCA-4138-B8F4-96CCD1298E83Q28592872-221AD204-C7FC-4256-84AA-71347821B4BFQ28757671-4120EB30-24DA-4D07-9069-03E37B1A28E4Q30369057-9B897B1D-C003-4C72-9CB5-24279C80585BQ30381288-9105F465-C625-4992-B8BD-663EEEC17E60Q30481530-D95E2C2F-6339-421A-A15E-10E9B88BFCF7Q30537732-AC32F79D-1DAF-49E8-99BA-0C46EBF71C7CQ30544278-4BC13635-3609-4E7C-84BA-31350C18CC41Q33390827-1F6E5323-FA94-44A4-8A16-FCDFA65D6D94Q33613170-F911E6BC-975D-4EAA-9E3D-A0EEB783213BQ33734076-0272D6C4-4669-41A8-B653-C20CFE5B9B9AQ33749501-4F9280AF-15AF-42A0-8D23-9DB2A468F9EAQ33905966-A6F07266-93F7-4726-8691-92497A9368D7Q34015950-EC5949A4-AD8B-49C4-8812-1CB0DA99BCC5Q34056577-34E01FCF-21BE-4206-8F03-E06DFC841B84Q34092616-1BE89B20-3219-4146-A20E-6A6FF3AEE942Q34122515-E326237E-6A6E-43DA-9BEB-B995744DF207Q34166108-AE3386CE-072E-41CA-8951-F30360CE3F77
P2860
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@ast
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@en
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@nl
type
label
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@ast
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@en
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@nl
prefLabel
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@ast
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@en
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@nl
P2093
P2860
P3181
P1433
P1476
Sensitivity to oxidative stres ...... model of primary Parkinsonism
@en
P2093
Alan Jonason
Asa Abeliovich
Cecile Martinat
Lichuan Yang
M Flint Beal
Shoshana Shendelman
Thomas Floss
Thomas Leete
P2860
P3181
P356
10.1371/JOURNAL.PBIO.0020327
P407
P577
2004-11-01T00:00:00Z