Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
about
The telomerase databaseIt all comes together at the ends: telomerase structure, function, and biogenesisMolecular regulation of telomerase activity in agingSingle-molecule analysis of telomerase structure and functionProgress in structural studies of telomeraseSelenium derivatization of nucleic acids for crystallographyTelomerase Regulation from Beginning to the EndStructure of active dimeric human telomerase.Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomeraseFunctional interaction between telomere protein TPP1 and telomeraseHuman telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivoInsights into the evolution of mammalian telomerase: platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomesExclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptasesMutation in TERT separates processivity from anchor-site function.Identification of human TERT elements necessary for telomerase recruitment to telomeres.Human telomerase: biogenesis, trafficking, recruitment, and activation.Protein-RNA interaction restricts telomerase from running through the stop sign.Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomeraseTelomerase structure.The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalizationA novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzymeA high-throughput immobilized bead screen for stable proteins and multi-protein complexes.The biogenesis and regulation of telomerase holoenzymesRibonucleoprotein multimers and their functions.InTERTpreting telomerase structure and functionArchitecture of human telomerase RNA.Regulated assembly and disassembly of the yeast telomerase quaternary complex.Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactionsDirect involvement of the TEN domain at the active site of human telomerasePrediction of RNA binding sites in proteins from amino acid sequenceHuman telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.The Pot1a-associated proteins Tpt1 and Pat1 coordinate telomere protection and length regulation in Tetrahymena.Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA.RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency.The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase.Characterization of physical and functional anchor site interactions in human telomerase.
P2860
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P2860
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
description
2006 nî lūn-bûn
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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
@ast
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
@en
type
label
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
@ast
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
@en
prefLabel
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
@ast
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
@en
P2860
P356
P1476
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
@en
P2093
Steven A Jacobs
P2860
P2888
P304
P356
10.1038/NSMB1054
P577
2006-02-05T00:00:00Z