Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons - Test2 - elhamkhani - TriplyDB

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

http://www.wikidata.org/entity/Q30524222

about

A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint.ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint.How Taxol/paclitaxel kills cancer cells.The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles.Restriction endonucleases from invasive Neisseria gonorrhoeae cause double-strand breaks and distort mitosis in epithelial cells during infection HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity Fluorescent foci quantitation for high-throughput analysis.miR-125b promotes cell death by targeting spindle assembly checkpoint gene MAD1 and modulating mitotic progression Tumorigenicity analysis of heterogeneous dental stem cells and its self-modification for chromosome instability.Colorectal cancer carcinogenesis: a review of mechanisms Cancer karyotypes: survival of the fittest 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.MAD2γ, a novel MAD2 isoform, reduces mitotic arrest and is associated with resistance in testicular germ cell tumors.BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer EWSR1 regulates mitosis by dynamically influencing microtubule acetylation.Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos.Therapeutic relevance of the protein phosphatase 2A in cancer.Genetic instability: tipping the balance.Genome-wide identification of differential methylation between primary and recurrent hepatocellular carcinomas.Emerging links among Chromosome Instability (CIN), cancer, and aging.Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma.Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.The Role of Aneuploidy in Cancer Evolution.Shugoshin1 enhances multidrug resistance of gastric cancer cells by regulating MRP1, Bcl-2, and Bax genes.Chk1-Mad2 interaction: a crosslink between the DNA damage checkpoint and the mitotic spindle checkpoint.In vitro anticancer drug test: A new method emerges from the model of glioma stem cells.Mad1 at the Golgi apparatus: a story beyond kinetochores.Determinants of robustness in spindle assembly checkpoint signalling.Increased expression of mitotic arrest deficient-like 1 (MAD1L1) is associated with poor prognosis and insensitive to Taxol treatment in breast cancer.

P2860

Q27316820-5D7A7EBC-0D27-4962-98B3-A2F3A7438439 Q33811933-F54E4C50-1072-493A-9290-13FCBC11468B Q34040203-EE0CFB24-950E-4F7A-93F8-E6409986C5C8 Q34040591-605A6A11-F72B-4392-A263-8085E0F8B9A9 Q34166802-8E826283-8993-48D7-A881-60641B91C331 Q34166850-0A1D6324-21FE-48D6-AB18-2C27A2348AA9 Q34250840-5DCC88A5-52AF-4939-8587-9004317AB353 Q34612444-C2BC3C1A-04BD-40CE-8E15-A9C59F6CBFE5 Q35742468-31CC4999-2B48-411A-8C3F-D5B3DAF533BF Q35773951-1E835F7A-51C1-4B9E-AB1A-3981A4F445E2 Q35961828-41B93363-5291-4A77-B74B-3934D23CA794 Q36609152-E81C3D9F-804E-4266-AED4-860F1F8D832D Q36780809-BD058212-AE92-4399-9232-1A0177E7C5E5 Q36849645-40ED0278-058A-412C-B8EF-849647797910 Q36909580-C252ED5D-7ED4-4FFF-809E-A8E91E4A6AA8 Q37078688-3DF5F91A-11C7-41F3-A8EF-0BC29696B111 Q37143221-0C03A8DE-8ADC-45B5-B95D-5824A45D6772 Q37180403-2679074C-B165-42E2-9C70-E56A20954FBC Q37194523-9D86B2CE-D98F-415A-A2B2-124C1BEC4175 Q37302999-93E88DE7-A149-4505-9275-16DDEC3A7757 Q37641636-55AE2CFA-20C2-4121-870C-E276294075D0 Q38068039-707BD5F9-EC68-4E16-BD7C-31D1B5D5314C Q38857159-A69527E3-2C70-4D5B-AD88-E9C5916C6F94 Q38929880-1926C046-13F8-4A58-998C-0F7821BF0F52 Q39038787-6A6FA790-D0CB-4F5A-8807-DA1EC974F942 Q39044653-87DE012B-809A-4A72-969D-6EB7AA87BA21 Q39066291-046388F5-E52B-4E15-AB36-B0ECE7B9C022 Q39169792-F1C5C366-B130-4D46-B62E-22B0413F5C5F Q40483960-E2A68863-8020-48A7-95C6-0B89D9C97C05 Q41681466-074440FD-DE46-41C4-BFD0-F1CE5115D4D6 Q42008337-9C901191-E6F5-4874-9DD3-A07BE7F319F3 Q44713577-057435B3-E412-4F9D-A197-B168B9EEE211 Q47994894-91D9F240-A438-474E-B777-10095398684D

P2860

Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons

http://www.wikidata.org/entity/Q30524222

description

2012 nî lūn-bûn

@nan

2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Up-regulation of the mitotic c ...... istance to microtubule poisons

@ast

Up-regulation of the mitotic c ...... istance to microtubule poisons

@en

type

label

Up-regulation of the mitotic c ...... istance to microtubule poisons

@ast

Up-regulation of the mitotic c ...... istance to microtubule poisons

@en

prefLabel

Up-regulation of the mitotic c ...... istance to microtubule poisons

@ast

Up-regulation of the mitotic c ...... istance to microtubule poisons

@en

P1433

Q30524222-9537D1A0-ADED-4330-83BC-98D9E16DEBBA

P1476

Q30524222-3A30730E-AF3A-4340-9424-6D4350FD9B83

P2093

Q30524222-03C6DC77-BA71-43A7-BB7E-41C8CF83E422

Q30524222-972EFAFD-B6CD-4CC3-9BDA-032A0B500836

Q30524222-A72B47E0-8E49-4233-A5A7-22CCB22BF42A

Q30524222-A7805A88-C6ED-4034-9A3E-B4B92E2AAFF0

Q30524222-CD57E1D2-A813-44CB-A46A-165AE787C6A6

Q30524222-E3F7ED0E-1FB2-4C70-9710-893743037B11

Q30524222-FE033358-2194-4E4E-A9A7-5CF70B14E906

P2860

Q30524222-01137341-E7F3-492A-828E-31CE34D668A9

Q30524222-03C7CEFB-3E75-4A64-9460-6DA9BDC243D6

Q30524222-055600A5-7CF0-422C-B54B-D5E25CFB5D1A

Q30524222-0D1CC88E-BAAF-44C7-A9DB-B46D8142A4F9

Q30524222-0F3FB6E5-6A33-4122-B727-AAFFFF51F360

Q30524222-0FF2E4F2-8DA5-4493-AC14-1CCBA398658C

Q30524222-10C17477-CF31-4DBA-95B3-0B77F42366EC

Q30524222-11499443-596E-4110-937E-2C832125CFEA

Q30524222-19E24652-9BF2-4144-9799-F3388022883D

Q30524222-1DA7409E-9780-4B40-A377-56600633D0B6

P304

Q30524222-DB6D6D17-4A85-48C0-8157-550CB050DA56

P31

Q30524222-F29D5D8F-567E-4A4F-8C27-B5F23F309B16

P356

Q30524222-985102FD-0215-4933-B965-271C6582698F

P407

Q30524222-BC345D91-3A72-4257-BE3D-74FEE706FE87

P433

Q30524222-412EF398-B145-42A1-9E79-1F05056CF70F

P478

Q30524222-27360558-A25D-404A-9070-349C59FFF3F7

P577

Q30524222-3D02FC50-3534-440B-842F-89C28160A827

P5875

Q30524222-33B44278-136F-4B0A-9DEE-CDD7113F0365

P698

Q30524222-D4141207-BC02-46AE-9D70-2058F465769F

P921

Q30524222-a269e25c-3e3f-4d9e-8300-241ebea14b15

P932

Q30524222-6C684365-EEA7-497A-8154-7A61CEEED50C

P356

PNAS.1201911109

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Up-regulation of the mitotic c ...... istance to microtubule poisons

@en

P2093

Anjon Audhya

http://www.w3.org/2001/XMLSchema#string

Avtar Roopra

http://www.w3.org/2001/XMLSchema#string

Beth A Weaver

http://www.w3.org/2001/XMLSchema#string

Eric M C Britigan

http://www.w3.org/2001/XMLSchema#string

Kristen Witte

http://www.w3.org/2001/XMLSchema#string

Lauren M Zasadil

http://www.w3.org/2001/XMLSchema#string

Sean D Ryan

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

ZW10 links mitotic checkpoint signaling to the structural kinetochore.

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

Mutations of mitotic checkpoint genes in human cancers

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

P304

E2205-14

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1201911109

http://www.w3.org/2001/XMLSchema#string

P407

P433

33

http://www.w3.org/2001/XMLSchema#string

P478

109

http://www.w3.org/2001/XMLSchema#string

P577

2012-07-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

229016327

http://www.w3.org/2001/XMLSchema#string

P698

22778409

http://www.w3.org/2001/XMLSchema#string

P921

P932

3421180

http://www.w3.org/2001/XMLSchema#string