Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation
about
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpointInhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsThe tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complexMad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointRapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cellsDual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylationStructure of the mitotic checkpoint complexAma1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II.Spatiotemporal regulation of the anaphase-promoting complex in mitosisEmi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteinsIn-silico modeling of the mitotic spindle assembly checkpointTAp73 regulates the spindle assembly checkpoint by modulating BubR1 activityUp-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsIn vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopySpindle checkpoint requires Mad1-bound and Mad1-free Mad2.The spindle checkpoint, aneuploidy, and cancer.Attributes of short linear motifs.Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae.Changes in the localization of the Saccharomyces cerevisiae anaphase-promoting complex upon microtubule depolymerization and spindle checkpoint activation.Inducing precocious anaphase in cultured mammalian cells.The spindle checkpoint: structural insights into dynamic signalling.Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complexRegulation of Fertility by the p53 Family Members.Meiotic control of the APC/C: similarities & differences from mitosis.Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregationBubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulationPhosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint.Panta rhei: the APC/C at steady state.Spatial rule-based modeling: a method and its application to the human mitotic kinetochore.Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint.In silico spatial simulations reveal that MCC formation and excess BubR1 are required for tight inhibition of the anaphase-promoting complex.Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control.The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.
P2860
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P2860
Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification of an overlappi ...... spindle checkpoint regulation
@ast
Identification of an overlappi ...... spindle checkpoint regulation
@en
Identification of an overlappi ...... spindle checkpoint regulation
@nl
type
label
Identification of an overlappi ...... spindle checkpoint regulation
@ast
Identification of an overlappi ...... spindle checkpoint regulation
@en
Identification of an overlappi ...... spindle checkpoint regulation
@nl
prefLabel
Identification of an overlappi ...... spindle checkpoint regulation
@ast
Identification of an overlappi ...... spindle checkpoint regulation
@en
Identification of an overlappi ...... spindle checkpoint regulation
@nl
P2860
P3181
P1476
Identification of an overlappi ...... spindle checkpoint regulation
@en
P2860
P304
P3181
P356
10.1128/MCB.21.15.5190-5199.2001
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P577
2001-08-01T00:00:00Z