Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.
about
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpointp31comet blocks Mad2 activation through structural mimicryStructural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interactionShugoshin is a Mad1/Cdc20-like interactor of Mad2Determinants of conformational dimerization of Mad2 and its inhibition by p31cometIdentification of a MAD2-binding protein, CMT2, and its role in mitosis.Sgt1 is required for human kinetochore assemblyConformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpointThe multifaceted roles of the HORMA domain in cellular signalingA Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2.Structure of the mitotic checkpoint complexMad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint.A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete developmentIn-silico modeling of the mitotic spindle assembly checkpointPurification and characterization of a DNA-binding recombinant PREP1:PBX1 complexCondensin confers the longitudinal rigidity of chromosomes.The anaphase promoting complex/cyclosome: a machine designed to destroyStructure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsRZZ and Mad1 dynamics in Drosophila mitosis.Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.The influence of catalysis on mad2 activation dynamics.Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversineThe ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregationMad2 phosphorylation regulates its association with Mad1 and the APC/C.Inducing precocious anaphase in cultured mammalian cells.The spindle checkpoint: structural insights into dynamic signalling.TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switchingClosed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)Mad2 and Mad3 cooperate to arrest budding yeast in mitosis.MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancerp31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2.Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans
P2860
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P2860
Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Mad2 binding to Mad1 and Cdc20 ...... red for the spindle checkpoint
@nl
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@ast
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@en
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@en-gb
type
label
Mad2 binding to Mad1 and Cdc20 ...... red for the spindle checkpoint
@nl
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@ast
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@en
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@en-gb
prefLabel
Mad2 binding to Mad1 and Cdc20 ...... red for the spindle checkpoint
@nl
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@ast
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@en
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@en-gb
P2093
P2860
P50
P356
P1433
P1476
Mad2 binding to Mad1 and Cdc20 ...... ed for the spindle checkpoint.
@en
P2093
Melixetian M
Prosperini E
P2860
P304
P356
10.1093/EMBOJ/20.22.6371
P407
P577
2001-11-01T00:00:00Z