Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
about
KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 ExpressionNetwork-Based Biomedical Data Analysis.Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.Histone demethylase JMJD1C regulates esophageal cancer proliferation Via YAP1 signaling.MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylationPD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma.Epigenetic therapies by targeting aberrant histone methylome in AML: molecular mechanisms, current preclinical and clinical development.The story of protein arginine methylation: characterization, regulation, and function.Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies.MYC-Master Regulator of the Cancer Epigenome and Transcriptome.Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid LeukemiaHistone demethylase JMJD2C: epigenetic regulators in tumors.Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC.Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development.Transcriptional memory of cells of origin overrides β-catenin requirement of MLL cancer stem cells.The PAF complex regulation of Prmt5 facilitates the progression and maintenance of MLL fusion leukemia.Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML.MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity.
P2860
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P2860
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
description
2016 nî lūn-bûn
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2016 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@ast
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@en
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@nl
type
label
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@ast
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@en
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@nl
prefLabel
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@ast
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@en
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@nl
P2093
P2860
P1433
P1476
Targeting Aberrant Epigenetic ...... M4C in Acute Myeloid Leukemia.
@en
P2093
Bernd B Zeisig
Chi Wai Eric So
Jayant K Rane
Katie Holmes
Kerri A Mowen
Li Chong Chan
Michael G Finn
Ngai Cheung
Tsz Kan Fung
P2860
P356
10.1016/J.CCELL.2015.12.007
P577
2016-01-01T00:00:00Z