A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds. - Test2 - elhamkhani - TriplyDB

A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.

A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.

http://www.wikidata.org/entity/Q35055050

about

Undirected, Homogeneous C-H Bond Functionalization: Challenges and Opportunities Recent progress in the metabolic engineering of alkaloids in plant systems Optimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolites Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variant Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin Structural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3 Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3 Application of a fluorescence-based continuous-flow bioassay to screen for diversity of cytochrome P450 BM3 mutant libraries.A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.Identification of mutant Asp251Gly/Gln307His of cytochrome P450 BM3 for the generation of metabolites of diclofenac, ibuprofen and tolbutamide.Regio- and stereoselective hydroxylation of 10-undecenoic acid with a light-driven P450 BM3 biocatalyst yielding a valuable synthon for natural product synthesis.Enzymatic functionalization of carbon-hydrogen bonds.Cytochrome P450: taming a wild type enzyme Characterization of diverse natural variants of CYP102A1 found within a species of Bacillus megaterium.Drug Oxidation by Cytochrome P450BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types.P450(BM3) (CYP102A1): connecting the dots.Drug metabolism in microorganisms.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.The application of engineered liver tissues for novel drug discovery.Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope.Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11.Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization.Engineering of human CYP3A enzymes by combination of activating polymorphic variants.Heterologous expression of CYP102A5 variant from Bacillus cereus CYPPB-1: Validation of model for predicting drug metabolism of human P450 probe substrates.Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli.Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis.Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms.Hydroxylation of anilides by engineered cytochrome P450BM3.The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac.An artificial self-sufficient cytochrome P450 directly nitrates fluorinated tryptophan analogs with a different regio-selectivity.Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone.Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450 Variant Cytochromes P450 as useful biocatalysts: addressing the limitations Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis

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A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.

http://www.wikidata.org/entity/Q35055050

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年论文

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A panel of cytochrome P450 BM3 ...... and diversify lead compounds.

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A panel of cytochrome P450 BM3 ...... and diversify lead compounds.

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A panel of cytochrome P450 BM3 ...... and diversify lead compounds.

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Chemistry: A European Journal

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A panel of cytochrome P450 BM3 ...... and diversify lead compounds.

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Andrew M Sawayama

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Horst Hemmerle

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Michael M Y Chen

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Ming-Shang Kuo

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Palaniappan Kulanthaivel

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P2860

Structure-guided recombination creates an artificial family of cytochromes P450.

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

Alkane C–H activation and functionalization with homogeneous transition metal catalysts: a century of progress—a new millennium in prospect

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.

A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.

Cytochrome P-450 3A4: regulation and role in drug metabolism.

Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida

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10.1002/CHEM.200900643

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