Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling. - Test2 - elhamkhani - TriplyDB

Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling.

Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling.

http://www.wikidata.org/entity/Q33349284

about

Engineered IgG1-Fc--one fragment to bind them all Applications of Yeast Surface Display for Protein Engineering Microbial enzymes: tools for biotechnological processes Cells and cell lysates: a direct approach for engineering antibodies against membrane proteins using yeast surface display A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain A De Novo Protein Binding Pair By Computational Design and Directed Evolution Molecular Basis of a Million-Fold Affinity Maturation Process in a Protein–Protein Interaction Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold Computational Design of a Protein-Based Enzyme Inhibitor A current perspective on applications of macrocyclic-peptide-based high-affinity ligands Artificial affinity proteins as ligands of immunoglobulins Directed Evolution of a Highly Specific FN3 Monobody to the SH3 Domain of Human Lyn Tyrosine Kinase.Isolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase.Ultrasound Molecular Imaging of the Breast Cancer Neovasculature using Engineered Fibronectin Scaffold Ligands: A Novel Class of Targeted Contrast Ultrasound Agent Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn.Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display.Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold Stability and CDR composition biases enrich binder functionality landscapes.Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging.PCRless library mutagenesis via oligonucleotide recombination in yeast NextGen protein design.Adnectins: engineered target-binding protein therapeutics ScaffoldSeq: Software for characterization of directed evolution populations.Shortened engineered human antibody CH2 domains: increased stability and binding to the human neonatal Fc receptor.Human monoclonal antibody fragments binding to insulin-like growth factors I and II with picomolar affinity.Bacterial display in combinatorial protein engineering.Epidermal growth factor receptor downregulation by small heterodimeric binding proteins Foundations for the design and implementation of synthetic genetic circuits.Engineered Fc based antibody domains and fragments as novel scaffolds.Optimization of ordered plasmid assembly by gap repair in Saccharomyces cerevisiae.Strategies to control the binding mode of de novo designed protein interactions.Peptide aptamers: development and applications.The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold Interactions Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties Engineered antibody variable and constant domains as therapeutic candidates.Directed evolution of a yeast-displayed HIV-1 SOSIP gp140 spike protein toward improved expression and affinity for conformational antibodies.Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.

P2860

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P2860

Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling.

http://www.wikidata.org/entity/Q33349284

description

2008 nî lūn-bûn

@nan

2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.

@ast

Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.

@en

type

label

Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.

@ast

Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.

@en

prefLabel

Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.

@ast

Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.

@en

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P2860

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Q33349284-0EF51B61-7E16-41E0-A2C2-2962C695ECF1

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Q33349284-A999FCC9-FF20-437F-9BAC-F39C57AA2D98

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Q33349284-9C9BB40A-161E-490A-B189-F7D58C24DA1C

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P932

Q33349284-D767513A-82D5-412B-B221-64CC516553FE

P356

J.JMB.2008.06.051

P1433

Journal of Molecular Biology

P1476

Picomolar affinity fibronectin ...... tagenesis, and loop shuffling.

@en

P2093

Atul Kapila

http://www.w3.org/2001/XMLSchema#string

Benjamin J Hackel

http://www.w3.org/2001/XMLSchema#string

K Dane Wittrup

http://www.w3.org/2001/XMLSchema#string

P2860

The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions

In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity

Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor.

High-affinity single-domain binding proteins with a binary-code interface

Rapid evolution of a protein in vitro by DNA shuffling

Molecular recognition properties of FN3 monobodies that bind the Src SH3 domain.

Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin.

Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display.

By-passing immunization: building high affinity human antibodies by chain shuffling.

High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold.

P304

1238-1252

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P31

scholarly article

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10.1016/J.JMB.2008.06.051

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P407

P433

5

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P478

381

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P577

2008-06-24T00:00:00Z

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P698

18602401

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P932

2840393

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