Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. - Test2 - elhamkhani - TriplyDB

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.

http://www.wikidata.org/entity/Q33411281

about

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity Computational approaches in target identification and drug discovery Understanding Genotype-Phenotype Effects in Cancer via Network Approaches Fundamentals of protein interaction network mapping Integrative approaches for finding modular structure in biological networks Identification of aberrant pathways and network activities from high-throughput data The benefits of humanized yeast models to study Parkinson's disease Annotating individual human genomes Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae Global analysis of condition-specific subcellular protein distribution and abundance Pathway connectivity and signaling coordination in the yeast stress-activated signaling network.Engineering enhanced protein disaggregases for neurodegenerative disease Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein Identifying causal genes and dysregulated pathways in complex diseases Large-scale elucidation of drug response pathways in humans Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening Genomics and bioinformatics of Parkinson's disease Evaluating diabetes and hypertension disease causality using mouse phenotypes Functional and regulatory profiling of energy metabolism in fission yeast Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling.Computational solutions for omics data.From data towards knowledge: revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data ResponseNet2.0: Revealing signaling and regulatory pathways connecting your proteins and genes--now with human data.Network analysis of GWAS data PheNetic: network-based interpretation of molecular profiling data Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data.Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks.Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models Characterizing regulatory path motifs in integrated networks using perturbational data.Modeling Huntington disease in yeast: perspectives and future directions.Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.Application of a systems approach to study developmental gene regulation.EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population.The yeast deletion collection: a decade of functional genomics Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

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Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.

http://www.wikidata.org/entity/Q33411281

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Bridging high-throughput genet ...... s to alpha-synuclein toxicity.

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Bridging high-throughput genet ...... s to alpha-synuclein toxicity.

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type

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Bridging high-throughput genet ...... s to alpha-synuclein toxicity.

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Bridging high-throughput genet ...... s to alpha-synuclein toxicity.

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Bridging high-throughput genet ...... s to alpha-synuclein toxicity.

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Nature Genetics

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Bridging high-throughput genet ...... s to alpha-synuclein toxicity.

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Aaron D Gitler

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Anil G Cashikar

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David R Karger

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Julie S Valastyan

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Linhui Julie Su

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Melissa L Geddie

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Oliver D King

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Pavan K Auluck

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Integrating phenotypic and expression profiles to map arsenic-response networks

Discovery of biological networks from diverse functional genomic data.

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

Alpha-synuclein in Lewy bodies

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10.1038/NG.337

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3

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41

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Ernest Fraenkel

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24032254

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19234470

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