Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.
about
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicityDroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for DrosophilaModel systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityComputational approaches in target identification and drug discoveryUnderstanding Genotype-Phenotype Effects in Cancer via Network ApproachesFundamentals of protein interaction network mappingIntegrative approaches for finding modular structure in biological networksIdentification of aberrant pathways and network activities from high-throughput dataThe benefits of humanized yeast models to study Parkinson's diseaseAnnotating individual human genomesPredictive medicine: outcomes, challenges and opportunities in the Synergy-COPD projectPhosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseaseOxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiaeGlobal analysis of condition-specific subcellular protein distribution and abundancePathway connectivity and signaling coordination in the yeast stress-activated signaling network.Engineering enhanced protein disaggregases for neurodegenerative diseaseParkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synucleinIdentifying causal genes and dysregulated pathways in complex diseasesLarge-scale elucidation of drug response pathways in humansGeneration of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug ScreeningGenomics and bioinformatics of Parkinson's diseaseEvaluating diabetes and hypertension disease causality using mouse phenotypesFunctional and regulatory profiling of energy metabolism in fission yeastLinking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling.Computational solutions for omics data.From data towards knowledge: revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation dataResponseNet2.0: Revealing signaling and regulatory pathways connecting your proteins and genes--now with human data.Network analysis of GWAS dataPheNetic: network-based interpretation of molecular profiling dataDecoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data.Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks.Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease modelsCharacterizing regulatory path motifs in integrated networks using perturbational data.Modeling Huntington disease in yeast: perspectives and future directions.Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.Application of a systems approach to study developmental gene regulation.EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population.The yeast deletion collection: a decade of functional genomicsDefects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS
P2860
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P2860
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Bridging high-throughput genet ...... s to alpha-synuclein toxicity.
@ast
Bridging high-throughput genet ...... s to alpha-synuclein toxicity.
@en
type
label
Bridging high-throughput genet ...... s to alpha-synuclein toxicity.
@ast
Bridging high-throughput genet ...... s to alpha-synuclein toxicity.
@en
prefLabel
Bridging high-throughput genet ...... s to alpha-synuclein toxicity.
@ast
Bridging high-throughput genet ...... s to alpha-synuclein toxicity.
@en
P2093
P2860
P50
P356
P1433
P1476
Bridging high-throughput genet ...... s to alpha-synuclein toxicity.
@en
P2093
Aaron D Gitler
Anil G Cashikar
David R Karger
Julie S Valastyan
Linhui Julie Su
Melissa L Geddie
Oliver D King
Pavan K Auluck
P2860
P2888
P304
P356
10.1038/NG.337
P407
P577
2009-02-22T00:00:00Z
P5875
P6179
1039470729