Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. - Test2 - elhamkhani - TriplyDB

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

http://www.wikidata.org/entity/Q33616462

about

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export Glucocerebrosidase is shaking up the synucleinopathies Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion Diseases The unfolded protein response in neurodegenerative diseases: a neuropathological perspective Using iPS Cells toward the Understanding of Parkinson's Disease Mitochondrial targets for pharmacological intervention in human disease iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development Glucocerebrosidase and Parkinson disease: Recent advances Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells Animal modeling an oligodendrogliopathy--multiple system atrophy Spreading of pathology in neurodegenerative diseases: a focus on human studies Engineering enhanced protein disaggregases for neurodegenerative disease Identification of TMEM230 mutations in familial Parkinson's disease Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 Efforts to make and apply humanized yeast Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration Human pluripotent stem cells on artificial microenvironments: a high content perspective Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells.Solving the puzzle of Parkinson's disease using induced pluripotent stem cells.Endoplasmic reticulum stress and inflammation in the central nervous system eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress Induced Pluripotent Stem Cells: Global Research Trends.Creation of a library of induced pluripotent stem cells from Parkinsonian patients.Pathological alpha-synuclein propagates through neural networks Calcineurin determines toxic versus beneficial responses to α-synuclein.RNA metabolism in the pathogenesis of Parkinson׳s disease The Autism Spectrum Disorders Stem Cell Resource at Children's Hospital of Orange County: Implications for Disease Modeling and Drug Discovery Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication Induced Pluripotent Stem Cells Meet Genome Editing Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.Transcriptomics of maternal and fetal membranes can discriminate between gestational-age matched preterm neonates with and without cognitive impairment diagnosed at 18-24 months.Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain Probing disorders of the nervous system using reprogramming approaches.Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree.Scope and limitations of yeast as a model organism for studying human tissue-specific pathways.

P2860

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P2860

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

http://www.wikidata.org/entity/Q33616462

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

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2013年論文

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2013年论文

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name

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

@ast

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

@en

type

label

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

@ast

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

@en

prefLabel

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

@ast

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

@en

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SCIENCE.1245296

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Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

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Alison E Mungenast

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Birgitt Schüle

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Chee Yeun Chung

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Daniel F Tardiff

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Dimitri Krainc

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Frank Soldner

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Joseph R Mazzulli

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Li-Huei Tsai

http://www.w3.org/2001/XMLSchema#string

Maisam Mitalipova

http://www.w3.org/2001/XMLSchema#string

Nathan T Jui

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P2860

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Investigating synapse formation and function using human pluripotent stem cell-derived neurons

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration

Biochemistry of mobile zinc and nitric oxide revealed by fluorescent sensors.

alpha-Synuclein locus triplication causes Parkinson's disease

An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport

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983-987

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10.1126/SCIENCE.1245296

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342

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Michael D. Pluth

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Rudolf Jaenisch

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2013-10-24T00:00:00Z

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258044524

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24158904

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Parkinson's disease

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4022187

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