Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway. - Test2 - elhamkhani - TriplyDB

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.

http://www.wikidata.org/entity/Q33481554

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The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling A balance between elongation and trimming regulates telomere stability in stem cells Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.Expression of Shelterin component POT1 is associated with decreased telomere length and immunity condition in humans with severe aplastic anemia Single molecule studies of physiologically relevant telomeric tails reveal POT1 mechanism for promoting G-quadruplex unfolding.The formation and stabilization of a novel G-quadruplex in the 5'-flanking region of the relaxin gene.Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability.A small molecule inhibitor of Pot1 binding to telomeric DNA.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.G-quadruplexes in viruses: function and potential therapeutic applications.TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.A Personal History of Quadruplex-Small Molecule Targeting.The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region.Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity Compromised genomic integrity impedes muscle growth after Atrx inactivation.Mechanism of the antiproliferative activity of some naphthalene diimide G-quadruplex ligands.Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase.Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells.On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts Folding and misfolding pathways of G-quadruplex DNA.Structural identity of telomeric complexes.Dynamics of telomeric chromatin at the crossroads of aging and cancer.Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.Telomeres as targets for anticancer therapies.Experimental approaches to identify cellular G-quadruplex structures and functions.G-quadruplexes: targets and tools in anticancer drug design.G-quadruplexes as potential therapeutic targets for embryonal tumors.The meiosis-specific modification of mammalian telomeres.Chromatin dynamics of plant telomeres and ribosomal genes.Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.

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P2860

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.

http://www.wikidata.org/entity/Q33481554

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Stabilization of quadruplex DN ...... pendent ATM signaling pathway.

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Stabilization of quadruplex DN ...... pendent ATM signaling pathway.

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type

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Stabilization of quadruplex DN ...... pendent ATM signaling pathway.

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Stabilization of quadruplex DN ...... pendent ATM signaling pathway.

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Stabilization of quadruplex DN ...... pendent ATM signaling pathway.

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Stabilization of quadruplex DN ...... pendent ATM signaling pathway.

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Stabilization of quadruplex DN ...... pendent ATM signaling pathway.

@en

P2093

Carmen D'Angelo

http://www.w3.org/2001/XMLSchema#string

Eric Gilson

http://www.w3.org/2001/XMLSchema#string

Gabriella Zupi

http://www.w3.org/2001/XMLSchema#string

Malcolm F Stevens

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian telomeres end in a large duplex loop

Normal human chromosomes have long G-rich telomeric overhangs at one end

Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats

The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair

TRF2 Protects Human Telomeres from End-to-End Fusions

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

Shelterin: the protein complex that shapes and safeguards human telomeres

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Unwinding the molecular basis of the Werner syndrome.

Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function.

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10.1093/NAR/GKP582

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16

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37

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Annamaria Biroccio

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2009-07-13T00:00:00Z

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26665504

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19596811

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2760797

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