Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
about
Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearingTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationMammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.Telomere shortening and apoptosis in telomerase-inhibited human tumor cellsCytotoxic T cell immunity against telomerase reverse transcriptase in humansComplex roles for telomeres and telomerase in breast carcinogenesisModels of breast cancer: quo vadis, animal modeling?A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytesTelomeres in aging and disease: lessons from zebrafishThe short and long telomere syndromes: paired paradigms for molecular medicineAlternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progressionTelomere shortening in human diseasesCancer stem cells: relevance to clinical transplantationArsenic inhibition of telomerase transcription leads to genetic instabilityDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsA highly selective telomerase inhibitor limiting human cancer cell proliferationNatural and pharmacological regulation of telomeraseRestoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.Carcinogenesis in mouse and human cells: parallels and paradoxes.Molecular and genetic aspects of lung cancer.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Telomere dysfunction triggers developmentally regulated germ cell apoptosis.Cell senescence and cancer.Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNADisruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout miceConstitutive telomerase expression promotes mammary carcinomas in aging mice.Telomerase recognizes its template by using an adjacent RNA motif.G-quadruplex nucleic acids and human diseaseThe telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progressionTelomerase extracurricular activities.Tumour immunotherapy: new tools, new treatment modalities and new T-cell antigens.The essence of senescence.Telomere maintenance mechanisms as a target for drug development.The role of TGFBI in mesothelioma and breast cancer: association with tumor suppression.Telomere dysfunction suppresses multiple endocrine neoplasia in mice.Telomere dynamics and homeostasis in a transmissible cancerCooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer developmentTelomerase and cancer: time to move from a promising target to a clinical reality.Telomeres, aging and cancer: in search of a happy ending.
P2860
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P2860
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Short dysfunctional telomeres ...... (delta2/3) cancer-prone mouse.
@ast
Short dysfunctional telomeres ...... (delta2/3) cancer-prone mouse.
@en
type
label
Short dysfunctional telomeres ...... (delta2/3) cancer-prone mouse.
@ast
Short dysfunctional telomeres ...... (delta2/3) cancer-prone mouse.
@en
prefLabel
Short dysfunctional telomeres ...... (delta2/3) cancer-prone mouse.
@ast
Short dysfunctional telomeres ...... (delta2/3) cancer-prone mouse.
@en
P2093
P1433
P1476
Short dysfunctional telomeres ...... (delta2/3) cancer-prone mouse.
@en
P2093
DePinho RA
Gottlieb GJ
Greenberg RA
P304
P356
10.1016/S0092-8674(00)80761-8
P407
P577
1999-05-01T00:00:00Z