Generating chromosome instability through the simultaneous deletion of Mad2 and p53. - Test2 - elhamkhani - TriplyDB

Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

http://www.wikidata.org/entity/Q33910498

about

A role of WT1 in cell division and genomic stability Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity Ploidy variation in multinucleate cells changes under stress.Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.WT1 interacts with MAD2 and regulates mitotic checkpoint function Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas.Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer.DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans.Surveillance mechanism linking Bub1 loss to the p53 pathway.Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure Chromosome Biorientation.Linking stem cells to chromosomal instability.DNA polymerase zeta is required for proliferation of normal mammalian cells.Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia.Spindle checkpoint function and cellular sensitivity to antimitotic drugs.Aneuploidy and tumorigenesis.Spindle assembly checkpoint, aneuploidy and tumorigenesis.Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice Mechanisms of chromosomal instability.Studying chromosome instability in the mouse.Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice.Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.Chromosomal instability and aneuploidy in cancer: from yeast to man Genome instability: does genetic diversity amplification drive tumorigenesis?Genetic instability: tipping the balance.The cancer biology of whole-chromosome instability.Gene copy-number alterations: a cost-benefit analysis.The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity.Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.MAD2DeltaC induces aneuploidy and promotes anchorage-independent growth in human prostate epithelial cells.

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P2860

Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

http://www.wikidata.org/entity/Q33910498

description

2005 nî lūn-bûn

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2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2005 թվականի հուլիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

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Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

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type

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Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

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Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

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prefLabel

Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

@ast

Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

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Proceedings of the National Academy of Sciences of the United States of America

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Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

@en

P2093

Annegret Schulze Lutum

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Aurora A Burds

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Peter K Sorger

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P2860

Identification of a human mitotic checkpoint gene: hsMAD2

Mutations of mitotic checkpoint genes in human cancers

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

The role of chromosomal instability in tumor initiation.

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae.

The spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain.

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.

Feedback control of mitosis in budding yeast

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