Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. - Test2 - elhamkhani - TriplyDB

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

http://www.wikidata.org/entity/Q30480363

about

The nuclear envelopathies and human diseases MTBP plays a crucial role in mitotic progression and chromosome segregation The role of aneuploidy in promoting and suppressing tumors Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers When 2+2=5: the origins and fates of aneuploid and tetraploid cells Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis Aneuploidy in stem cells Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation Identification of genes that are essential to restrict genome duplication to once per cell division Novel interactions between actin and the proteasome revealed by complex haploinsufficiency Osteosarcomagenesis: modeling cancer initiation in the mouse.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses.Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain Mitotic chromosomal instability and cancer: mouse modelling of the human disease.ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.Linking genetics to structural biology: complex heterozygosity screening with actin alanine scan alleles identifies functionally related surfaces on yeast actin.The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.Fat tissue, aging, and cellular senescence.The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.Chromosome missegregation causes colon cancer by APC loss of heterozygosity.Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest.Spartan deficiency causes genomic instability and progeroid phenotypes.The ageing epigenome: damaged beyond repair?Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas.Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function.Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging Aneuploidy: instigator and inhibitor of tumorigenesis.

P2860

Q21284427-D323581E-D598-448A-B59E-41DA220BDCB0 Q24338557-3B49940E-9281-41E9-B102-E370BE406806 Q24648182-FAACCE0F-2865-488B-AE6F-BE461FB5032F Q24656162-75A5A72F-723D-4F79-98B0-29475D650291 Q24658364-FA9CFA28-044B-45DA-94F2-5FBAF195747F Q24682464-6D346671-410C-404E-A632-C50B7D03A551 Q26746154-21BB561C-F573-4C75-B91A-D43D458F31CC Q26858894-E043ADF1-0EAA-430A-B160-B5E01B21CE3F Q26998944-F9E541D6-5C8B-4295-BE8B-E3BABA12EF45 Q27329025-712D1AD2-3381-4F1D-B811-730F137AE781 Q27336129-723B8A19-81E8-4CD8-8972-FBF16A5569B0 Q28478743-C052B0E0-FDDF-46E6-983B-0DEDAC09F246 Q28593144-EC0A374E-9978-48F3-A5C5-C84D79C02905 Q28593938-26ADBE9E-747F-438D-AEF5-E0E420050502 Q28820756-BCA142E5-DC4F-4071-83AF-2E33B42F55AE Q30430569-F54FA795-7288-4C04-AA13-8093A85F5394 Q30476415-A5CF49CC-C2D9-4F8F-AAEA-1B3D75A59682 Q30524222-505DD321-42BC-492F-9504-5A6E6DD63E6F Q30556712-73B46B62-32EC-43C0-98A1-18A2F2B5F371 Q33616502-3397D226-3CB6-4F7C-84A4-43B3704BBBF8 Q33826217-CF459621-3C38-43F1-9691-0A22EDD5815A Q33850635-933A9F9B-4792-4F87-8152-F62AF1A6957E Q33926467-D326ED38-347A-4A12-8248-7DBD844EE5B1 Q33978787-7909529C-3B30-4D00-8E10-58B16958E204 Q34042411-D90AE4C5-9515-40CB-B713-BA0B6B728CA7 Q34069561-C9C7B8A6-A56C-46E6-8E8A-C72F739B6734 Q34128617-8902676D-317A-4ED4-A5EA-5A0B31CB941E Q34130783-3ADA3E7B-7310-428E-9D5B-39AA2C27FD08 Q34166850-F59700E8-B699-4CF8-AA74-06BB0735C1B1 Q34218211-557E98B2-D615-48E1-92DE-C3557ED772DB Q34218789-5131A7DE-426E-42CB-97FD-24C13317690D Q34239366-A47474FC-6E16-444A-976F-01EE7A1A3B83 Q34317812-771E6579-9464-4DF1-AE34-ED3E90AE5624 Q34585406-187F5BA4-A13B-4857-875E-7E3EC08DF03B Q34722436-2DF9056C-2F02-4AA7-A82D-9D0E5C8DBDBF Q34980757-6F325170-73C1-4687-A79A-7404E3E928C1 Q35020477-84713DE1-E341-4B7D-BE58-12F5159E78A7 Q35041278-FD96C5C5-8A06-48FE-9624-231611F254D5 Q35093156-8E6CA57F-079D-4378-A2A2-017A6935CC45 Q35094418-785B2091-C5B3-444E-BCF0-728DC7A42B1C

P2860

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

http://www.wikidata.org/entity/Q30480363

description

2006 nî lūn-bûn

@nan

2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

@ast

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

@en

type

label

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

@ast

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

@en

prefLabel

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

@ast

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

@en

P1433

Q30480363-4882BE52-C86D-45F8-823E-0605A9B6C305

P1476

Q30480363-B34AE35C-3492-4832-9A7F-220C556256E2

P2093

Q30480363-0A20DA31-E638-409F-A146-B10DC5E991F2

Q30480363-52998DAD-E8E7-4D07-9F42-9BF066898526

Q30480363-81A71B50-8001-461B-A2F1-659D32F05EAB

Q30480363-AAE1B1EA-77EE-445C-AF55-7DAED990F814

Q30480363-BE0B5CF4-D061-448B-91A2-901ADB4B3112

Q30480363-E8FB82D9-ECB5-47E5-A6EE-24EE56DF1DD6

P2860

Q30480363-1D681E75-55A4-44A2-99F5-4C611B00A857

Q30480363-2E29F7DF-5986-40EF-8753-585E14C871FF

Q30480363-2F6F1188-6240-4BE3-91CA-4540D495E10E

Q30480363-3C8EE23F-1D68-4644-B2E7-A41F05D311D9

Q30480363-3D6CC5F2-D8C3-426E-848B-FC1E80B5F46F

Q30480363-44F28328-0FE3-4653-B0F1-D09F9B8FAFEF

Q30480363-45FC3C5B-09AF-4F07-A5C3-8F61CFEE8127

Q30480363-4606B26A-CAFE-41CC-A274-A7BC26D29182

Q30480363-4C2D43E7-B570-4EA2-85D2-94FEFFDBDD58

Q30480363-4DD31843-023D-4D11-B190-FDA2FDA88470

P304

Q30480363-E53D4498-0E6A-4B23-9145-44D58ACEF653

P31

Q30480363-3A940DB3-0F9D-4597-9A97-C1435159D060

P356

Q30480363-A43C3A52-6BA6-43C4-AFFC-A81DDECFC1DE

P407

Q30480363-4164A298-C2F5-4D26-9150-1D5BA1B62B7A

P433

Q30480363-7A961154-70A7-46DA-8413-14409E0B98CF

P478

Q30480363-40975C63-FF86-411B-ABBE-1733A69506F4

P577

Q30480363-53ADE741-8B14-42BD-8890-38BA95642B95

P5875

Q30480363-4F5E8BFA-895C-4140-80C4-1D9E51A80CFD

P698

Q30480363-465EE625-0E1F-4214-A7FC-63C181E7EACA

P921

Q30480363-343E2669-4B22-4CF5-9F24-A8C8D6141584

P932

Q30480363-A38A68C8-2818-47B9-BE43-C74DCC833969

P356

P1433

Journal of Cell Biology

P1476

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.

@en

P2093

Andre Terzic

http://www.w3.org/2001/XMLSchema#string

Carmen Perez-Terzic

http://www.w3.org/2001/XMLSchema#string

Darren J Baker

http://www.w3.org/2001/XMLSchema#string

Jan M A van Deursen

http://www.w3.org/2001/XMLSchema#string

Karthik B Jeganathan

http://www.w3.org/2001/XMLSchema#string

Liviu Malureanu

http://www.w3.org/2001/XMLSchema#string

P2860

RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

Processing, localization, and requirement of human separase for normal anaphase progression

Regulation of human separase by securin binding and autocleavage

mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function

P304

529-540

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1083/JCB.200507081

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

172

http://www.w3.org/2001/XMLSchema#string

P577

2006-02-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7299770

http://www.w3.org/2001/XMLSchema#string

P698

16476774

http://www.w3.org/2001/XMLSchema#string

P921

haploinsufficiency

P932

2063673

http://www.w3.org/2001/XMLSchema#string