Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
about
Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosisThe DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cellsThe human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignmentSil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpointHuman Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplicationLoading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activityBub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesisInsights into APC/C: from cellular function to diseases and therapeuticsDNA damage associated with mitosis and cytokinesis failureFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisMouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function.The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association.The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteinsCentromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)atedAneuploid colon cancer cells have a robust spindle checkpointIn-silico modeling of the mitotic spindle assembly checkpointSpindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo developmentDisruption of the pelota gene causes early embryonic lethality and defects in cell cycle progression.Mouse emi1 has an essential function in mitotic progression during early embryogenesisInactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferationImpaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear proteinDivergent evolutionary rates in vertebrate and mammalian specific conserved non-coding elements (CNEs) in echolocating mammalsEarly aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshinTemporal and spatial regulation of translation in the mammalian oocyte via the mTOR-eIF4F pathwayProliferation of aneuploid human cells is limited by a p53-dependent mechanism.Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytesRegulation of APC/C activators in mitosis and meiosis.Generating chromosome instability through the simultaneous deletion of Mad2 and p53.A high-throughput platform for lentiviral overexpression screening of the human ORFeome.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Usp7 protects genomic stability by regulating Bub3.Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex.Reovirus-induced alterations in gene expression related to cell cycle regulation.Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling
P2860
Q21142712-B5FDA2A3-AD3C-4BD8-B9F9-81AC08CA7500Q24296443-294E96A0-A187-4CD2-AED7-4C99A7843411Q24302341-2D518DC7-356D-443F-8C4A-AE01D1282DFAQ24306626-C82FD6CD-E5A9-426D-970D-C4C09C62C35EQ24322809-5A5B02CB-011C-4EBD-8CB8-E9CECE377FDBQ24530007-3D8AA6DC-6093-4B6B-8256-6B7CA1346DFDQ24536263-23ECCC6A-71AE-4906-9705-1BFF3F29B6D7Q24540385-D1899EC1-46F9-4599-A28C-69B3870C8D49Q24564215-D4A38519-B9FE-43B8-8062-7BA80EF95437Q24679269-75ABF1DE-82AC-4193-B52F-1276999C5F4EQ24682464-D9626171-992E-4489-BA7E-302885A0C929Q26740196-3926C214-B9DC-4B13-90A6-B9CC5399B7ABQ26991874-32E6F8A6-0BB0-4BB2-8E29-C05F9D069EACQ26998944-7F32C950-1072-4A96-B919-5F44E0E41DCDQ27321241-499C408F-68DF-46A9-9283-95B4F42F349FQ27933960-8E597A20-1CCF-4D93-A7DC-7D319B738D0BQ27938665-20553636-AAAF-4BB8-B574-611A4ACEB144Q28188970-8879FEA6-317D-4B8B-9D93-412786940D69Q28217564-B318487A-9652-4D60-A932-0F5F10A8E38AQ28343940-7ECE1C7D-99D7-4BE9-A902-67A4A1AB956CQ28472091-FDE28890-FA23-43BA-9382-48B07E594491Q28478743-D11602A3-5DF4-4210-8EC4-549796A444A6Q28507942-0EF4441D-F725-4A2F-9CED-BB9F73A1EB58Q28508271-5ED191F2-88B8-4CD1-8C2E-F4F7D1902064Q28593938-954475D1-0FAA-4400-9B59-BD5E631D4C13Q28595006-DF17D122-70CD-4AFD-823E-511B33FF20ADQ28651719-1DE3BEFB-CF6B-41B6-908F-6F6287D3AA5BQ30480363-8F968C97-6787-485D-988D-8E3C18670525Q30489580-5D6B9215-06B8-4EEF-9547-78A8FDBC55DEQ30619646-63530A5C-F65B-4224-82D5-48BCC4936FA7Q33643740-049414B3-5068-4430-AA00-C75BB34D386BQ33763645-8A658C47-7BE4-4A9C-B184-ABA5E8050274Q33805690-24FC5524-BD7A-4CC2-80A6-DF29546322DAQ33910498-3B898C03-022E-441B-B450-97688A8EBF30Q33918260-50A08F57-4685-4329-94ED-A61929D74E07Q33926467-74A79376-D285-47D1-9F45-C9A90534F7F3Q33977038-BC50D3BF-DE14-45AD-8EF3-D7FB0034BD2DQ34166856-48D67734-979C-42F5-9E23-E6D21A330B0BQ34332403-2886824E-39E4-4995-8A98-4234C9FEFB53Q34407585-8224A976-0FEE-447B-9827-02BA38A62D9E
P2860
Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@ast
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@en
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@nl
type
label
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@ast
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@en
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@nl
prefLabel
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@ast
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@en
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@nl
P2093
P2860
P3181
P356
P1433
P1476
Bub3 gene disruption in mice r ...... ion during early embryogenesis
@en
P2093
P2860
P304
P3181
P356
10.1101/GAD.827500
P407
P577
2000-09-01T00:00:00Z