PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule? - Test2 - elhamkhani - TriplyDB

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

http://www.wikidata.org/entity/Q34042861

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A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA CRL4Cdt2: master coordinator of cell cycle progression and genome stability Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S‑phase cell cycle arrest and apoptosis through caspase/cyclin‑CDK pathways.Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos.Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.Impaired liver regeneration is associated with reduced cyclin B1 in natural killer T cell-deficient mice Quantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan Direct UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells.Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle.PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage COP9 signalosome function in the DDR.p21Cip1/Waf1 protein and its function based on a subcellular localization [corrected].Regulation of human DNA polymerase delta in the cellular responses to DNA damage.DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight.Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.Bimodal regulation of p21(waf1) protein as function of DNA damage levels.Gallotannin is a DNA damaging compound that induces senescence independently of p53 and p21 in human colon cancer cells.Toxicogenomic activity of gemcitabine in two TP53-mutated bladder cancer cell lines: special focus on cell cycle-related genes.Regulation and Modulation of Human DNA Polymerase δ Activity and Function.Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast.p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin.P21(Waf1/Cip1) depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway.Myosin 16 levels fluctuate during the cell cycle and are downregulated in response to DNA replication stress.Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway.

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P2860

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

http://www.wikidata.org/entity/Q34042861

description

2010 nî lūn-bûn

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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type

label

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

@ast

PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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J.DNAREP.2009.12.003

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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?

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Gastón Soria

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

Human DNA polymerase iota protects cells against oxidative stress

CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance

Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

WAF1, a potential mediator of p53 tumor suppression

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