DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1 - Test2 - elhamkhani - TriplyDB

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

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Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.Prevention of DNA re-replication in eukaryotic cells Replication licensing and cancer--a fatal entanglement?Mechanisms to control rereplication and implications for cancer.DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest A novel checkpoint mechanism regulating the G1/S transition CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation CRL4Cdt2: master coordinator of cell cycle progression and genome stability Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases.Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?Thymine DNA glycosylase is a CRL4Cdt2 substrate.Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Replication licensing and the DNA damage checkpoint.Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase A high ratio of G1 to G0 phase cells and an accumulation of G1 phase cells before S phase progression after injurious stimuli in the proximal tubule.Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy.Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways.Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase.Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis.The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.The DNA damage response pathways: at the crossroad of protein modifications.Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.Once in a lifetime: strategies for preventing re-replication in prokaryotic and eukaryotic cells.Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated.PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage DNA replication licensing control and rereplication prevention.Ub-family modifications at the replication fork: Regulating PCNA-interacting components.Quality control in the initiation of eukaryotic DNA replication.CRL Ubiquitin Ligases and DNA Damage Response.Regulating DNA replication in eukarya.DnaA protein DNA-binding domain binds to Hda protein to promote inter-AAA+ domain interaction involved in regulatory inactivation of DnaA.PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions.

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DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

http://www.wikidata.org/entity/Q24672982

description

2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@ast

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@en

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@nl

type

label

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@ast

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@en

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@nl

prefLabel

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@ast

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@en

DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

@nl

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DNA damage induces Cdt1 proteo ...... way dependent on Cdt2 and Ddb1

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Emma Ralph

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Erik Boye

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Stephen E Kearsey

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P2860

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis

Preventing re-replication of chromosomal DNA.

The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex

The Cdt1 protein is required to license DNA for replication in fission yeast

Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage

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17039252

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