Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. - Test2 - elhamkhani - TriplyDB

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.

http://www.wikidata.org/entity/Q34146314

about

An ancient gene network is co-opted for teeth on old and new jaws Bare bones pattern formation: a core regulatory network in varying geometries reproduces major features of vertebrate limb development and evolution Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function A symphony of inner ear developmental control genes.Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization Mediator modulates Gli3-dependent Sonic hedgehog signaling Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development Gli proteins and the control of spinal-cord patterning Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Cilia/Ift protein and motor -related bone diseases and mouse models Review of the molecular development of the thumb: digit primera The making of differences between fins and limbs The Hedgehog signalling pathway in bone formation Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart Cilia and developmental signaling Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis Genetic evidence that SOST inhibits WNT signaling in the limb Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates GATA6 is a crucial regulator of Shh in the limb bud Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development Gas1 extends the range of Hedgehog action by facilitating its signaling Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord Primary cilia regulate Shh activity in the control of molar tooth number Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation Specific requirements of sonic hedgehog signaling during oligodendrocyte development Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3 The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

P2860

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P2860

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity.

http://www.wikidata.org/entity/Q34146314

description

2002 nî lūn-bûn

@nan

2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2002年の論文

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2002年論文

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2002年論文

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2002年論文

@zh-hk

2002年論文

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2002年論文

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2002年论文

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name

Shh and Gli3 are dispensable f ...... ate digit number and identity.

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Shh and Gli3 are dispensable f ...... ate digit number and identity.

@en

Shh and Gli3 are dispensable f ...... ate digit number and identity.

@nl

type

label

Shh and Gli3 are dispensable f ...... ate digit number and identity.

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Shh and Gli3 are dispensable f ...... ate digit number and identity.

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Shh and Gli3 are dispensable f ...... ate digit number and identity.

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prefLabel

Shh and Gli3 are dispensable f ...... ate digit number and identity.

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Shh and Gli3 are dispensable f ...... ate digit number and identity.

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Shh and Gli3 are dispensable f ...... ate digit number and identity.

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Shh and Gli3 are dispensable f ...... ate digit number and identity.

@en

P2093

Chin Chiang

http://www.w3.org/2001/XMLSchema#string

John F Fallon

http://www.w3.org/2001/XMLSchema#string

Randall D Dahn

http://www.w3.org/2001/XMLSchema#string

Yina Li

http://www.w3.org/2001/XMLSchema#string

Ying Litingtung

http://www.w3.org/2001/XMLSchema#string

P2860

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

Hedgehog signaling in animal development: paradigms and principles

Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene

The roles of FGFs in the early development of vertebrate limbs

Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development

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10.1038/NATURE01033

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6901

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418

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1000412063

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12198547

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